biostudies-literatureUnknown6Benitez J<h4>Background</h4> Thymic epithelial tumors (TETs) are rare malignancies of the anterior mediastinum with a high histopathological diversity from thymoma A to thymic carcinoma (TC). The biology of TETs is poorly understood and knowledge of the transcriptomic fingerprint of thymoma and TC is limited. Up to 30% of patients will develop associated autoimmune disorders, mainly myasthenia gravis (MG). We aimed to characterize main cancer activation pathways of TET subgroups. <h4>Methods</h4> We selected a representative balanced set of thymoma and TCs to analyze 24 main cancer activation pathways using gene expression throughout Oncology biomarker panel (2,562 genes). Tumor representative paraffin-embedded blocks were macrodissected. Then, we merged data with The Cancer Genome Atlas (TCGA) datMediastinum (Hong Kong, China)https://www.ebi.ac.uk/biostudies/studies/S-EPMC9792825biostudies-literatureAB008. Activated pathways of Thymic Epithelial Tumors: a RYTHMIC studyPMC9792825Thomas de Montpreville VLacroix LScoazec JMercier OGirard NSaulnier PFlorez-Arango JLambotte OBenitez JArana RMolina TJob BMussot SBesse BFadel EfalseAB008. Activated pathways of Thymic Epithelial Tumors: a RYTHMIC study<h4>Background</h4> Thymic epithelial tumors (TETs) are rare malignancies of the anterior mediastinum with a high histopathological diversity from thymoma A to thymic carcinoma (TC). The biology of TETs is poorly understood and knowledge of the transcriptomic fingerprint of thymoma and TC is limited. Up to 30% of patients will develop associated autoimmune disorders, mainly myasthenia gravis (MG). We aimed to characterize main cancer activation pathways of TET subgroups. <h4>Methods</h4> We selected a representative balanced set of thymoma and TCs to analyze 24 main cancer activation pathways using gene expression throughout Oncology biomarker panel (2,562 genes). Tumor representative paraffin-embedded blocks were macrodissected. Then, we merged data with The Cancer Genome Atlas (TCGA) dat2022-01-01T00:00:00Z2022 Jan2025-04-22T18:00:40.092Z2025-04-06T02:20:11.905ZS-EPMC9792825