{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Holm L"],"funding":["Novo Nordisk Fonden"],"pagination":["e4519"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9793968"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(1)"],"pubmed_abstract":["Structural comparison reveals remote homology that often fails to be detected by sequence comparison. The DALI web server (http://ekhidna2.biocenter.helsinki.fi/dali) is a platform for structural analysis that provides database searches and interactive visualization, including structural alignments annotated with secondary structure, protein families and sequence logos, and 3D structure superimposition supported by color-coded sequence and structure conservation. Here, we are using DALI to mine the AlphaFold Database version 1, which increased the structural coverage of protein families by 20%. We found 100 remote homologous relationships hitherto unreported in the current reference database for protein domains, Pfam 35.0. In particular, we linked 35 domains of unknown function (DUFs) to t"],"journal":["Protein science : a publication of the Protein Society"],"pubmed_title":["DALI shines a light on remote homologs: One hundred discoveries."],"pmcid":["PMC9793968"],"funding_grant_id":["NNF200C0065157"],"pubmed_authors":["Laiho A","Toronen P","Salgado M","Holm L"],"additional_accession":[]},"is_claimable":false,"name":"DALI shines a light on remote homologs: One hundred discoveries.","description":"Structural comparison reveals remote homology that often fails to be detected by sequence comparison. The DALI web server (http://ekhidna2.biocenter.helsinki.fi/dali) is a platform for structural analysis that provides database searches and interactive visualization, including structural alignments annotated with secondary structure, protein families and sequence logos, and 3D structure superimposition supported by color-coded sequence and structure conservation. Here, we are using DALI to mine the AlphaFold Database version 1, which increased the structural coverage of protein families by 20%. We found 100 remote homologous relationships hitherto unreported in the current reference database for protein domains, Pfam 35.0. In particular, we linked 35 domains of unknown function (DUFs) to t","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-07-14T22:40:17.937Z","creation":"2025-02-19T01:44:29.659Z"},"accession":"S-EPMC9793968","cross_references":{"pubmed":["36419248"],"doi":["10.1002/pro.4519"]}}