{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen HY"],"funding":["NIBIB NIH HHS","NCI NIH HHS"],"pagination":["2609-2620"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9794017"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["88(6)"],"pubmed_abstract":["<h4>Purpose</h4>To develop techniques and establish a workflow using hyperpolarized carbon-13 (<sup>13</sup> C) MRI and the pyruvate-to-lactate conversion rate (k<sub>PL</sub> ) biomarker to guide MR-transrectal ultrasound fusion prostate biopsies.<h4>Methods</h4>The integrated multiparametric MRI (mpMRI) exam consisted of a 1-min hyperpolarized <sup>13</sup> C-pyruvate EPI acquisition added to a conventional prostate mpMRI exam. Maps of k<sub>PL</sub> values were calculated, uploaded to a picture archiving and communication system and targeting platform, and displayed as color overlays on T<sub>2</sub> -weighted anatomic images. Abdominal radiologists identified <sup>13</sup> C research biopsy targets based on the general recommendation of focal lesions with k<sub>PL</sub>  >0.02(s<sup>-1"],"journal":["Magnetic resonance in medicine"],"pubmed_title":["Improving multiparametric MR-transrectal ultrasound guided fusion prostate biopsies with hyperpolarized <sup>13</sup> C pyruvate metabolic imaging: A technical development study."],"pmcid":["PMC9794017"],"funding_grant_id":["U01 EB026412","P41 EB013598","R01 CA238379","U01 CA232320"],"pubmed_authors":["Gebrezgiabhier D","Gordon JW","Aggarwal R","Cooperberg MR","Kurhanewicz J","Wang ZJ","Larson PEZ","Shinohara K","Nguyen HG","Vigneron DB","Westphalen AC","Carvajal L","Chen HY","Bok RA","Ohliger MA"],"additional_accession":[]},"is_claimable":false,"name":"Improving multiparametric MR-transrectal ultrasound guided fusion prostate biopsies with hyperpolarized <sup>13</sup> C pyruvate metabolic imaging: A technical development study.","description":"<h4>Purpose</h4>To develop techniques and establish a workflow using hyperpolarized carbon-13 (<sup>13</sup> C) MRI and the pyruvate-to-lactate conversion rate (k<sub>PL</sub> ) biomarker to guide MR-transrectal ultrasound fusion prostate biopsies.<h4>Methods</h4>The integrated multiparametric MRI (mpMRI) exam consisted of a 1-min hyperpolarized <sup>13</sup> C-pyruvate EPI acquisition added to a conventional prostate mpMRI exam. Maps of k<sub>PL</sub> values were calculated, uploaded to a picture archiving and communication system and targeting platform, and displayed as color overlays on T<sub>2</sub> -weighted anatomic images. Abdominal radiologists identified <sup>13</sup> C research biopsy targets based on the general recommendation of focal lesions with k<sub>PL</sub>  >0.02(s<sup>-1","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-05-28T01:32:11.688Z","creation":"2025-02-19T04:23:48.639Z"},"accession":"S-EPMC9794017","cross_references":{"pubmed":["35975978"],"doi":["10.1002/mrm.29399"]}}