biostudies-literatureChen HYNIBIB NIH HHSNCI NIH HHS2609-2620https://www.ebi.ac.uk/biostudies/studies/S-EPMC9794017biostudies-literatureUnknown88(6)<h4>Purpose</h4>To develop techniques and establish a workflow using hyperpolarized carbon-13 (¹³ C) MRI and the pyruvate-to-lactate conversion rate (k_PL ) biomarker to guide MR-transrectal ultrasound fusion prostate biopsies.<h4>Methods</h4>The integrated multiparametric MRI (mpMRI) exam consisted of a 1-min hyperpolarized ¹³ C-pyruvate EPI acquisition added to a conventional prostate mpMRI exam. Maps of k_PL values were calculated, uploaded to a picture archiving and communication system and targeting platform, and displayed as color overlays on T₂ -weighted anatomic images. Abdominal radiologists identified ¹³ C research biopsy targets based on the general recommendation of focal lesions with k_PL  >0.02(s<sup>-1Magnetic resonance in medicineImproving multiparametric MR-transrectal ultrasound guided fusion prostate biopsies with hyperpolarized ¹³ C pyruvate metabolic imaging: A technical development study.PMC9794017U01 EB026412P41 EB013598R01 CA238379U01 CA232320Gebrezgiabhier DGordon JWAggarwal RCooperberg MRKurhanewicz JWang ZJLarson PEZShinohara KNguyen HGVigneron DBWestphalen ACCarvajal LChen HYBok RAOhliger MAfalseImproving multiparametric MR-transrectal ultrasound guided fusion prostate biopsies with hyperpolarized ¹³ C pyruvate metabolic imaging: A technical development study.<h4>Purpose</h4>To develop techniques and establish a workflow using hyperpolarized carbon-13 (¹³ C) MRI and the pyruvate-to-lactate conversion rate (k_PL ) biomarker to guide MR-transrectal ultrasound fusion prostate biopsies.<h4>Methods</h4>The integrated multiparametric MRI (mpMRI) exam consisted of a 1-min hyperpolarized ¹³ C-pyruvate EPI acquisition added to a conventional prostate mpMRI exam. Maps of k_PL values were calculated, uploaded to a picture archiving and communication system and targeting platform, and displayed as color overlays on T₂ -weighted anatomic images. Abdominal radiologists identified ¹³ C research biopsy targets based on the general recommendation of focal lesions with k_PL  >0.02(s<sup>-12022-01-01T00:00:00Z2022 Dec2026-05-28T01:32:11.688Z2025-02-19T04:23:48.639ZS-EPMC97940173597597810.1002/mrm.29399