{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ozkan H"],"funding":["HORIZON EUROPE European Institute of Innovation and Technology","NIAMS NIH HHS","National Institute for Health Care Management Foundation"],"pagination":["689-701"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9794532"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(2)"],"pubmed_abstract":["Posttraumatic osteoarthritis (PTOA) is mostly treated via corticosteroid administration, and total joint arthroplasty continues to be the sole effective intervention in severe conditions. To assess the therapeutic potential of CCR2 targeting in PTOA, we used biodegradable microplates (µPLs) to achieve a slow and sustained intraarticular release of the CCR2 inhibitor RS504393 into injured knees and followed joint damage during disease progression. RS504393-loaded µPLs (RS-µPLs) were fabricated via a template-replica molding technique. A mixture of poly(lactic-co-glycolic acid) (PLGA) and RS504393 was deposited into 20 × 10 μm (length × height) wells in a polyvinyl alcohol (PVA) square-patterned template. After physicochemical and toxicological characterizations, the RS504393 release profile"],"journal":["Drug delivery and translational research"],"pubmed_title":["Sustained inhibition of CC-chemokine receptor-2 via intraarticular deposition of polymeric microplates in post-traumatic osteoarthritis."],"pmcid":["PMC9794532"],"funding_grant_id":["872648","R01 AR070821"],"pubmed_authors":["Di Francesco V","Granero-Molto F","Decuzzi P","Ozkan H","Di Francesco M","Willcockson H","Valdes-Fernandez J","Prosper F","Longobardi L"],"additional_accession":[]},"is_claimable":false,"name":"Sustained inhibition of CC-chemokine receptor-2 via intraarticular deposition of polymeric microplates in post-traumatic osteoarthritis.","description":"Posttraumatic osteoarthritis (PTOA) is mostly treated via corticosteroid administration, and total joint arthroplasty continues to be the sole effective intervention in severe conditions. To assess the therapeutic potential of CCR2 targeting in PTOA, we used biodegradable microplates (µPLs) to achieve a slow and sustained intraarticular release of the CCR2 inhibitor RS504393 into injured knees and followed joint damage during disease progression. RS504393-loaded µPLs (RS-µPLs) were fabricated via a template-replica molding technique. A mixture of poly(lactic-co-glycolic acid) (PLGA) and RS504393 was deposited into 20 × 10 μm (length × height) wells in a polyvinyl alcohol (PVA) square-patterned template. After physicochemical and toxicological characterizations, the RS504393 release profile","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-05-10T04:47:15.808Z","creation":"2025-04-06T13:52:26.257Z"},"accession":"S-EPMC9794532","cross_references":{"pubmed":["36109442"],"doi":["10.1007/s13346-022-01235-1"]}}