{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Short WD"],"funding":["National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["e22298"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9796147"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["36(7)"],"pubmed_abstract":["Endothelial progenitor cells (EPCs) contribute to de novo angiogenesis, tissue regeneration, and remodeling. Interleukin 10 (IL-10), an anti-inflammatory cytokine that primarily signals via STAT3, has been shown to drive EPC recruitment to injured tissues. Our previous work demonstrated that overexpression of IL-10 in dermal wounds promotes regenerative tissue repair via STAT3-dependent regulation of fibroblast-specific hyaluronan synthesis. However, IL-10's role and specific mode of action on EPC recruitment, particularly in dermal wound healing and neovascularization in both normal and diabetic wounds, remain to be defined. Therefore, inducible skin-specific STAT3 knockdown mice were studied to determine IL-10's impact on EPCs, dermal wound neovascularization and healing, and whether it "],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["IL-10 promotes endothelial progenitor cell infiltration and wound healing via STAT3."],"pmcid":["PMC9796147"],"funding_grant_id":["1R01GM111808NIH","R01 GM111808"],"pubmed_authors":["Vangapandu HV","Butte MJ","Keswani SG","Steen E","Kaul A","Olutoye OO","Templeman N","Blum AJ","Narmoneva DA","Moles CM","Bollyky PL","Balaji S","Crombleholme TM","Wang X","Short WD"],"additional_accession":[]},"is_claimable":false,"name":"IL-10 promotes endothelial progenitor cell infiltration and wound healing via STAT3.","description":"Endothelial progenitor cells (EPCs) contribute to de novo angiogenesis, tissue regeneration, and remodeling. Interleukin 10 (IL-10), an anti-inflammatory cytokine that primarily signals via STAT3, has been shown to drive EPC recruitment to injured tissues. Our previous work demonstrated that overexpression of IL-10 in dermal wounds promotes regenerative tissue repair via STAT3-dependent regulation of fibroblast-specific hyaluronan synthesis. However, IL-10's role and specific mode of action on EPC recruitment, particularly in dermal wound healing and neovascularization in both normal and diabetic wounds, remain to be defined. Therefore, inducible skin-specific STAT3 knockdown mice were studied to determine IL-10's impact on EPCs, dermal wound neovascularization and healing, and whether it ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-21T15:19:33.425Z","creation":"2025-04-21T15:19:33.425Z"},"accession":"S-EPMC9796147","cross_references":{"pubmed":["35670763"],"doi":["10.1096/fj.201901024RR"]}}