biostudies-literatureShort WDNational Institute of General Medical SciencesNIGMS NIH HHSe22298https://www.ebi.ac.uk/biostudies/studies/S-EPMC9796147biostudies-literatureUnknown36(7)Endothelial progenitor cells (EPCs) contribute to de novo angiogenesis, tissue regeneration, and remodeling. Interleukin 10 (IL-10), an anti-inflammatory cytokine that primarily signals via STAT3, has been shown to drive EPC recruitment to injured tissues. Our previous work demonstrated that overexpression of IL-10 in dermal wounds promotes regenerative tissue repair via STAT3-dependent regulation of fibroblast-specific hyaluronan synthesis. However, IL-10's role and specific mode of action on EPC recruitment, particularly in dermal wound healing and neovascularization in both normal and diabetic wounds, remain to be defined. Therefore, inducible skin-specific STAT3 knockdown mice were studied to determine IL-10's impact on EPCs, dermal wound neovascularization and healing, and whether it FASEB journal : official publication of the Federation of American Societies for Experimental BiologyIL-10 promotes endothelial progenitor cell infiltration and wound healing via STAT3.PMC97961471R01GM111808NIHR01 GM111808Vangapandu HVButte MJKeswani SGSteen EKaul AOlutoye OOTempleman NBlum AJNarmoneva DAMoles CMBollyky PLBalaji SCrombleholme TMWang XShort WDfalseIL-10 promotes endothelial progenitor cell infiltration and wound healing via STAT3.Endothelial progenitor cells (EPCs) contribute to de novo angiogenesis, tissue regeneration, and remodeling. Interleukin 10 (IL-10), an anti-inflammatory cytokine that primarily signals via STAT3, has been shown to drive EPC recruitment to injured tissues. Our previous work demonstrated that overexpression of IL-10 in dermal wounds promotes regenerative tissue repair via STAT3-dependent regulation of fibroblast-specific hyaluronan synthesis. However, IL-10's role and specific mode of action on EPC recruitment, particularly in dermal wound healing and neovascularization in both normal and diabetic wounds, remain to be defined. Therefore, inducible skin-specific STAT3 knockdown mice were studied to determine IL-10's impact on EPCs, dermal wound neovascularization and healing, and whether it 2022-01-01T00:00:00Z2022 Jul2025-04-21T15:19:33.425Z2025-04-21T15:19:33.425ZS-EPMC97961473567076310.1096/fj.201901024RR