biostudies-literatureUnknown63(9)Christensen JEpilepsiforeningen<h4>Objective</h4>The US Food and Drug Administration recently issued a warning against the use of the antiseizure medication lamotrigine in people at risk of cardiac rhythm and conduction abnormalities. This study assessed the risk of cardiac morbidity and mortality in new users of lamotrigine.<h4>Methods</h4>In a Danish population-based cohort study, we followed cohort members aged ≥15 years for the first 2 years after they initiated lamotrigine therapy. The main outcomes were cardiac conduction disorders in people without pre-existing cardiac morbidity and all-cause mortality in people with pre-existing cardiac morbidity. Cox proportional hazards models provided hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for comparison of the risk in current versus past users oEpilepsia2371-2380https://www.ebi.ac.uk/biostudies/studies/S-EPMC9796304biostudies-literatureCardiac morbidity and mortality associated with the use of lamotrigine.PMC9796304Christensen JTrabjerg BBDreier JWfalseCardiac morbidity and mortality associated with the use of lamotrigine.<h4>Objective</h4>The US Food and Drug Administration recently issued a warning against the use of the antiseizure medication lamotrigine in people at risk of cardiac rhythm and conduction abnormalities. This study assessed the risk of cardiac morbidity and mortality in new users of lamotrigine.<h4>Methods</h4>In a Danish population-based cohort study, we followed cohort members aged ≥15 years for the first 2 years after they initiated lamotrigine therapy. The main outcomes were cardiac conduction disorders in people without pre-existing cardiac morbidity and all-cause mortality in people with pre-existing cardiac morbidity. Cox proportional hazards models provided hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for comparison of the risk in current versus past users o2022-01-01T00:00:00Z2022 Sep2025-04-19T18:08:19.367Z2025-04-19T18:08:19.367ZS-EPMC97963043573521110.1111/epi.17339