{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yan Y"],"funding":["Vetenskapsrådet","European Research Council"],"pagination":["804-815"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9796397"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["292(5)"],"pubmed_abstract":["<h4>Background</h4>Metabolite profiles provide snapshots of the overall effect of numerous exposures accumulated over life courses, which may lead to health outcomes in the future.<h4>Objective</h4>We hypothesized that the risk of all-cause mortality is linked to alterations in metabolism earlier in life, which are reflected in plasma metabolite profiles. We aimed to identify plasma metabolites associated with future risk of all-cause mortality.<h4>Methods</h4>Through metabolomics, 110 metabolites were measured in 3833 individuals from the Malmö Diet and Cancer-Cardiovascular Cohort (MDC-CC). A total of 1574 deaths occurred within an average follow-up time of 22.2 years. Metabolites that were significantly associated with all-cause mortality in MDC-CC were replicated in 1500 individuals from Malmö Preventive Project re-examination (MPP), among whom 715 deaths occurred within an average follow-up time of 11.3 years.<h4>Results</h4>Twenty two metabolites were significantly associated with all-cause mortality in MDC-CC, of which 13 were replicated in MPP. Levels of trigonelline, glutamate, dimethylglycine, C18-1-carnitine, C16-1-carnitine, C14-1-carnitine, and 1-methyladenosine were associated with an increased risk, while levels of valine, tryptophan, lysine, leucine, histidine, and 2-aminoisobutyrate were associated with a decreased risk of all-cause mortality.<h4>Conclusion</h4>We used metabolomics in two Swedish prospective cohorts and identified replicable associations between 13 metabolites and future risk of all-cause mortality. Novel associations between five metabolites-C18-1-carnitine, C16-1-carnitine, C14-1-carnitine, trigonelline, and 2-aminoisobutyrate-and all-cause mortality were discovered. These findings suggest potential new biomarkers for the prediction of mortality and provide insights for understanding the biochemical pathways that lead to mortality."],"journal":["Journal of internal medicine"],"pubmed_title":["The association between plasma metabolites and future risk of all-cause mortality."],"pmcid":["PMC9796397"],"funding_grant_id":["2018‐02760","AdG 2019‐885003","SFO‐EXODIAB","2019‐61406","AdG 2019-885003"],"pubmed_authors":["Melander O","Smith E","Ottosson F","Yan Y"],"additional_accession":[]},"is_claimable":false,"name":"The association between plasma metabolites and future risk of all-cause mortality.","description":"<h4>Background</h4>Metabolite profiles provide snapshots of the overall effect of numerous exposures accumulated over life courses, which may lead to health outcomes in the future.<h4>Objective</h4>We hypothesized that the risk of all-cause mortality is linked to alterations in metabolism earlier in life, which are reflected in plasma metabolite profiles. We aimed to identify plasma metabolites associated with future risk of all-cause mortality.<h4>Methods</h4>Through metabolomics, 110 metabolites were measured in 3833 individuals from the Malmö Diet and Cancer-Cardiovascular Cohort (MDC-CC). A total of 1574 deaths occurred within an average follow-up time of 22.2 years. Metabolites that were significantly associated with all-cause mortality in MDC-CC were replicated in 1500 individuals from Malmö Preventive Project re-examination (MPP), among whom 715 deaths occurred within an average follow-up time of 11.3 years.<h4>Results</h4>Twenty two metabolites were significantly associated with all-cause mortality in MDC-CC, of which 13 were replicated in MPP. Levels of trigonelline, glutamate, dimethylglycine, C18-1-carnitine, C16-1-carnitine, C14-1-carnitine, and 1-methyladenosine were associated with an increased risk, while levels of valine, tryptophan, lysine, leucine, histidine, and 2-aminoisobutyrate were associated with a decreased risk of all-cause mortality.<h4>Conclusion</h4>We used metabolomics in two Swedish prospective cohorts and identified replicable associations between 13 metabolites and future risk of all-cause mortality. Novel associations between five metabolites-C18-1-carnitine, C16-1-carnitine, C14-1-carnitine, trigonelline, and 2-aminoisobutyrate-and all-cause mortality were discovered. These findings suggest potential new biomarkers for the prediction of mortality and provide insights for understanding the biochemical pathways that lead to mortality.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-26T00:24:44.201Z","creation":"2025-04-06T09:43:41.984Z"},"accession":"S-EPMC9796397","cross_references":{"pubmed":["35796403"],"doi":["10.1111/joim.13540"]}}