{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fan J"],"funding":["NIA NIH HHS","NHLBI NIH HHS","National Institutes of Health"],"pagination":["155249"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9796492"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["134"],"pubmed_abstract":["<h4>Background and purpose</h4>The senescence-accelerated mouse P1 (SAMP1) suffers from humoral immune deficiency, arterial stiffness and accelerated aging. In contrast, the microRNA-150 knockout (miR-150-KO) mice show enhanced humoral immune function including increased B cell population and elevated serum immunoglobulin levels and enjoy extended lifespan. The purpose of this study was to investigate whether transplantation of bone marrow cells (BMCs) from miR-150-KO mice affects immune deficiency and arterial stiffening in SAMP1 mice.<h4>Methods and results</h4>Pulse wave velocity and blood pressure were increased significantly in SAMP1 mice (10 months), indicating arterial stiffening and hypertension. Interestingly, transplantation of BMCs from miR-150-KO mice significantly attenuated a"],"journal":["Metabolism: clinical and experimental"],"pubmed_title":["Transplantation of bone marrow cells from miR150 knockout mice improves senescence-associated humoral immune dysfunction and arterial stiffness."],"pmcid":["PMC9796492"],"funding_grant_id":["R01 AG049780","AG049780","R01 HL154147","HL154147","R01 AG062375","R01 HL118558","R01 HL105302"],"pubmed_authors":["Fan J","Lu X","Wang S","Sun Z"],"additional_accession":[]},"is_claimable":false,"name":"Transplantation of bone marrow cells from miR150 knockout mice improves senescence-associated humoral immune dysfunction and arterial stiffness.","description":"<h4>Background and purpose</h4>The senescence-accelerated mouse P1 (SAMP1) suffers from humoral immune deficiency, arterial stiffness and accelerated aging. In contrast, the microRNA-150 knockout (miR-150-KO) mice show enhanced humoral immune function including increased B cell population and elevated serum immunoglobulin levels and enjoy extended lifespan. The purpose of this study was to investigate whether transplantation of bone marrow cells (BMCs) from miR-150-KO mice affects immune deficiency and arterial stiffening in SAMP1 mice.<h4>Methods and results</h4>Pulse wave velocity and blood pressure were increased significantly in SAMP1 mice (10 months), indicating arterial stiffening and hypertension. Interestingly, transplantation of BMCs from miR-150-KO mice significantly attenuated a","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-04T07:44:35.592Z","creation":"2024-11-06T07:02:26.849Z"},"accession":"S-EPMC9796492","cross_references":{"pubmed":["35792174"],"doi":["10.1016/j.metabol.2022.155249"]}}