biostudies-literatureFan JNIA NIH HHSNHLBI NIH HHSNational Institutes of Health155249https://www.ebi.ac.uk/biostudies/studies/S-EPMC9796492biostudies-literatureUnknown134<h4>Background and purpose</h4>The senescence-accelerated mouse P1 (SAMP1) suffers from humoral immune deficiency, arterial stiffness and accelerated aging. In contrast, the microRNA-150 knockout (miR-150-KO) mice show enhanced humoral immune function including increased B cell population and elevated serum immunoglobulin levels and enjoy extended lifespan. The purpose of this study was to investigate whether transplantation of bone marrow cells (BMCs) from miR-150-KO mice affects immune deficiency and arterial stiffening in SAMP1 mice.<h4>Methods and results</h4>Pulse wave velocity and blood pressure were increased significantly in SAMP1 mice (10 months), indicating arterial stiffening and hypertension. Interestingly, transplantation of BMCs from miR-150-KO mice significantly attenuated aMetabolism: clinical and experimentalTransplantation of bone marrow cells from miR150 knockout mice improves senescence-associated humoral immune dysfunction and arterial stiffness.PMC9796492R01 AG049780AG049780R01 HL154147HL154147R01 AG062375R01 HL118558R01 HL105302Fan JLu XWang SSun ZfalseTransplantation of bone marrow cells from miR150 knockout mice improves senescence-associated humoral immune dysfunction and arterial stiffness.<h4>Background and purpose</h4>The senescence-accelerated mouse P1 (SAMP1) suffers from humoral immune deficiency, arterial stiffness and accelerated aging. In contrast, the microRNA-150 knockout (miR-150-KO) mice show enhanced humoral immune function including increased B cell population and elevated serum immunoglobulin levels and enjoy extended lifespan. The purpose of this study was to investigate whether transplantation of bone marrow cells (BMCs) from miR-150-KO mice affects immune deficiency and arterial stiffening in SAMP1 mice.<h4>Methods and results</h4>Pulse wave velocity and blood pressure were increased significantly in SAMP1 mice (10 months), indicating arterial stiffening and hypertension. Interestingly, transplantation of BMCs from miR-150-KO mice significantly attenuated a2022-01-01T00:00:00Z2022 Sep2025-04-04T07:44:35.592Z2024-11-06T07:02:26.849ZS-EPMC97964923579217410.1016/j.metabol.2022.155249