{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["61(40)"],"submitter":["Hador R"],"pubmed_abstract":["The production of L-lactide from L-lactic acid involves a substantial formation of meso-lactide as an impurity, and, upon polymerization with the industrial catalyst tin octanoate, results in poly(L-lactic acid) of reduced crystallinity due to stereoerrors randomly distributed along the polymer chains. We describe a new approach wherein, instead of avoiding stereoerrors by removing the meso-lactide prior to polymerization, the stereoerrors in the polymer are tolerated, by crowding them in a stereogradient copolymer. A zirconium complex of an amine tris(phenolate) ligand is found to exhibit very high syndioselectivity in the ring opening polymerization catalysis of meso-lactide at room temperature, and gives rise to stereogradient copolymers in the polymerization of mixtures of meso-lactide"],"journal":["Angewandte Chemie (International ed. in English)"],"pagination":["e202207652"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9796763"],"repository":["biostudies-literature"],"pubmed_title":["Stereogradient Poly(Lactic Acid) from meso-Lactide/L-Lactide Mixtures."],"pmcid":["PMC9796763"],"pubmed_authors":["Kol M","Venditto V","Shuster M","Hador R"],"additional_accession":[]},"is_claimable":false,"name":"Stereogradient Poly(Lactic Acid) from meso-Lactide/L-Lactide Mixtures.","description":"The production of L-lactide from L-lactic acid involves a substantial formation of meso-lactide as an impurity, and, upon polymerization with the industrial catalyst tin octanoate, results in poly(L-lactic acid) of reduced crystallinity due to stereoerrors randomly distributed along the polymer chains. We describe a new approach wherein, instead of avoiding stereoerrors by removing the meso-lactide prior to polymerization, the stereoerrors in the polymer are tolerated, by crowding them in a stereogradient copolymer. A zirconium complex of an amine tris(phenolate) ligand is found to exhibit very high syndioselectivity in the ring opening polymerization catalysis of meso-lactide at room temperature, and gives rise to stereogradient copolymers in the polymerization of mixtures of meso-lactide","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T10:59:20.734Z","creation":"2025-04-04T10:59:20.734Z"},"accession":"S-EPMC9796763","cross_references":{"pubmed":["35789524"],"doi":["10.1002/anie.202207652"]}}