{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["110(24)"],"submitter":["Aldahabi M"],"pubmed_abstract":["A stunning example of synaptic diversity is the postsynaptic target cell-type-dependent difference in synaptic efficacy in cortical networks. Here, we show that CA1 pyramidal cell (PC) to fast spiking interneuron (FSIN) connections have 10-fold larger release probability (P<sub>v</sub>) than those on oriens lacunosum-moleculare (O-LM) interneurons. Freeze-fracture immunolabeling revealed that different nano-topologies and coupling distances between Ca<sup>2+</sup> channels and release sites (RSs) are not responsible for the distinct P<sub>v</sub>. Although [Ca<sup>2+</sup>] transients are 40% larger in FSINs innervating boutons, when [Ca<sup>2+</sup>] entry is matched in the two bouton populations, EPSCs in O-LM cells are still 7-fold smaller. However, application of a phorbol ester analog"],"journal":["Neuron"],"pagination":["4144-4161.e7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9796815"],"repository":["biostudies-literature"],"pubmed_title":["Different priming states of synaptic vesicles underlie distinct release probabilities at hippocampal excitatory synapses."],"pmcid":["PMC9796815"],"pubmed_authors":["Holderith N","Aldahabi M","Balint F","Reva M","Nusser Z","Lorincz A"],"additional_accession":[]},"is_claimable":false,"name":"Different priming states of synaptic vesicles underlie distinct release probabilities at hippocampal excitatory synapses.","description":"A stunning example of synaptic diversity is the postsynaptic target cell-type-dependent difference in synaptic efficacy in cortical networks. Here, we show that CA1 pyramidal cell (PC) to fast spiking interneuron (FSIN) connections have 10-fold larger release probability (P<sub>v</sub>) than those on oriens lacunosum-moleculare (O-LM) interneurons. Freeze-fracture immunolabeling revealed that different nano-topologies and coupling distances between Ca<sup>2+</sup> channels and release sites (RSs) are not responsible for the distinct P<sub>v</sub>. Although [Ca<sup>2+</sup>] transients are 40% larger in FSINs innervating boutons, when [Ca<sup>2+</sup>] entry is matched in the two bouton populations, EPSCs in O-LM cells are still 7-fold smaller. However, application of a phorbol ester analog","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-22T18:00:55.175Z","creation":"2025-04-06T02:20:16.164Z"},"accession":"S-EPMC9796815","cross_references":{"pubmed":["36261033"],"doi":["10.1016/j.neuron.2022.09.035"]}}