biostudies-literatureBurnell MThe Eve AppealMedical Research CouncilNIHR Biomedical Research Centre, University College London HospitalsNHS Innovation Accelerator1970-1980https://www.ebi.ac.uk/biostudies/studies/S-EPMC9796935biostudies-literatureUnknown129(12)<h4>Objective</h4>Ashkenazi-Jewish (AJ) population-based BRCA testing is acceptable, cost-effective and amplifies primary prevention for breast & ovarian cancer. However, data describing lifestyle impact are lacking. We report long-term results of population-based BRCA testing on lifestyle behaviour and cancer risk perception.<h4>Design</h4>Two-arm randomised controlled trials (ISRCTN73338115, GCaPPS): (a) population-screening (PS); (b) family history (FH)/clinical criteria testing.<h4>Setting</h4>North London AJ-population.<h4>Population/sample</h4>AJ women/men >18 years.<h4>Exclusions</h4>prior BRCA testing or first-degree relatives of BRCA-carriers.<h4>Methods</h4>Participants were recruited through self-referral. All participants received informed pre-test genetic counselling. The inteBJOG : an international journal of obstetrics and gynaecologyRandomised trial of population-based BRCA testing in Ashkenazi Jews: long-term secondary lifestyle behavioural outcomes.PMC9796935GTCVPTMC_UU_00004/01Wardle JBurnell MSanderson SLegood RBeller USobocan MTomlinson IBrady AFDesai RLoggenberg KJacobs IMenon UGessler SGaba FDorkins HJacobs CSide LWallis YManchanda RfalseRandomised trial of population-based BRCA testing in Ashkenazi Jews: long-term secondary lifestyle behavioural outcomes.<h4>Objective</h4>Ashkenazi-Jewish (AJ) population-based BRCA testing is acceptable, cost-effective and amplifies primary prevention for breast & ovarian cancer. However, data describing lifestyle impact are lacking. We report long-term results of population-based BRCA testing on lifestyle behaviour and cancer risk perception.<h4>Design</h4>Two-arm randomised controlled trials (ISRCTN73338115, GCaPPS): (a) population-screening (PS); (b) family history (FH)/clinical criteria testing.<h4>Setting</h4>North London AJ-population.<h4>Population/sample</h4>AJ women/men >18 years.<h4>Exclusions</h4>prior BRCA testing or first-degree relatives of BRCA-carriers.<h4>Methods</h4>Participants were recruited through self-referral. All participants received informed pre-test genetic counselling. The inte2022-01-01T00:00:00Z2022 Nov2025-04-04T10:59:00.284Z2025-04-04T10:59:00.284ZS-EPMC97969353578176810.1111/1471-0528.17253