{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hjortdal J"],"funding":["Agence Nationale de la Recherche"],"pagination":["2337-2347"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9796948"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(10)"],"pubmed_abstract":["Acute rejection (AR) of corneal transplants (CT) has a profound effect on subsequent graft survival but detailed immunological studies in human CT recipients are lacking. In this multi-site, cross-sectional study, clinical details and blood samples were collected from adults with clinically diagnosed AR of full-thickness (FT)-CT (n = 35) and posterior lamellar (PL)-CT (n = 21) along with Stable CT recipients (n = 177) and adults with non-transplanted corneal disease (n = 40). For those with AR, additional samples were collected 3 months later. Immune cell analysis was performed by whole-genome microarrays (whole blood) and high-dimensional multi-color flow cytometry (peripheral blood mononuclear cells). For both, no activation signature was identified within the B cell and T cell repertoir"],"journal":["American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"],"pubmed_title":["Peripheral blood immune cell profiling of acute corneal transplant rejection."],"pmcid":["PMC9796948"],"funding_grant_id":["ANR‐10‐IBHU‐005","ANR‐17‐CE17‐0008"],"pubmed_authors":["Brouard S","Griffin MD","Pleyer U","Bylesjo M","Karakachoff M","Armitage WJ","Hjortdal J","Gabhann PM","Gourraud PA","Walkinshaw MD","Degauque N","Vabres B","Cadoux M","Murphy CC","Tole D"],"additional_accession":[]},"is_claimable":false,"name":"Peripheral blood immune cell profiling of acute corneal transplant rejection.","description":"Acute rejection (AR) of corneal transplants (CT) has a profound effect on subsequent graft survival but detailed immunological studies in human CT recipients are lacking. In this multi-site, cross-sectional study, clinical details and blood samples were collected from adults with clinically diagnosed AR of full-thickness (FT)-CT (n = 35) and posterior lamellar (PL)-CT (n = 21) along with Stable CT recipients (n = 177) and adults with non-transplanted corneal disease (n = 40). For those with AR, additional samples were collected 3 months later. Immune cell analysis was performed by whole-genome microarrays (whole blood) and high-dimensional multi-color flow cytometry (peripheral blood mononuclear cells). For both, no activation signature was identified within the B cell and T cell repertoir","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T10:59:08.34Z","creation":"2025-04-04T10:59:08.34Z"},"accession":"S-EPMC9796948","cross_references":{"pubmed":["35704290"],"doi":["10.1111/ajt.17119"]}}