biostudies-literatureUnknown13Raimundo AF<h4>Introduction</h4>Diabetes is one of the major metabolic diseases worldwide. Despite being a complex systemic pathology, the aggregation and deposition of Islet Amyloid Polypeptide (IAPP), or amylin, is a recognized histopathological marker of the disease. Although IAPP proteotoxicity represents an important trigger of β-cell dysfunction and ultimately death, its exploitation as a therapeutic tool remains underdeveloped. The bioactivity of (poly)phenols towards inhibition of pathological protein aggregation is well known, however, most of the identified molecules have limited bioavailability.<h4>Methods</h4>Using a strategy combining in silico, cell-free and cell studies, we scrutinized a unique in-house collection of (poly)phenol metabolites predicted to appear in the human circulationFrontiers in endocrinology1008418https://www.ebi.ac.uk/biostudies/studies/S-EPMC9797523biostudies-literatureUrolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes.PMC9797523Dos Santos DJVAFerreira SMenezes RBrito JARaimundo AFSaraiva NLopes-da-Silva MPobre VDos Santos CNfalseUrolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes.<h4>Introduction</h4>Diabetes is one of the major metabolic diseases worldwide. Despite being a complex systemic pathology, the aggregation and deposition of Islet Amyloid Polypeptide (IAPP), or amylin, is a recognized histopathological marker of the disease. Although IAPP proteotoxicity represents an important trigger of β-cell dysfunction and ultimately death, its exploitation as a therapeutic tool remains underdeveloped. The bioactivity of (poly)phenols towards inhibition of pathological protein aggregation is well known, however, most of the identified molecules have limited bioavailability.<h4>Methods</h4>Using a strategy combining in silico, cell-free and cell studies, we scrutinized a unique in-house collection of (poly)phenol metabolites predicted to appear in the human circulation2022-01-01T00:00:00Z20222025-04-26T05:19:19.069Z2025-02-19T01:57:12.027ZS-EPMC97975233658982610.3389/fendo.2022.1008418