{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Qin C"],"pubmed_abstract":["<h4>Introduction</h4>Spinal cord injury (SCI) often causes continuous neurological damage to clinical patients. Circular RNAs (circRNAs) are related to a lot of diseases, including SCI. We previously found five candidate circRNAs which were likely to regulate the secondary pathophysiological changes in rat model after traumatic SCI.<h4>Methods</h4>In this study, we first selected and overexpressed target circRNA in rats. We then explored its functional roles using various functional assays in a rat model after SCI.<h4>Results</h4>We found that rno-circRNA-013017-the selected target circRNA-reduced neuron apoptosis, preserved the survival and activity of motor neurons, and regulated apoptosis-related proteins at 3 days post-SCI using western blot, immunofluorescence and polymerase chain rea"],"journal":["Frontiers in neuroscience"],"pagination":["1065897"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9797719"],"repository":["biostudies-literature"],"pubmed_title":["Inhibition by rno-circRNA-013017 of the apoptosis of motor neurons in anterior horn and descending axonal degeneration in rats after traumatic spinal cord injury."],"pmcid":["PMC9797719"],"pubmed_authors":["Liu Y","Talifu Z","Zhao LX","Zhang X","Liu JY","Jing YL","Li JJ","Gao F","Xu PP","Qin C","Bai F","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Inhibition by rno-circRNA-013017 of the apoptosis of motor neurons in anterior horn and descending axonal degeneration in rats after traumatic spinal cord injury.","description":"<h4>Introduction</h4>Spinal cord injury (SCI) often causes continuous neurological damage to clinical patients. Circular RNAs (circRNAs) are related to a lot of diseases, including SCI. We previously found five candidate circRNAs which were likely to regulate the secondary pathophysiological changes in rat model after traumatic SCI.<h4>Methods</h4>In this study, we first selected and overexpressed target circRNA in rats. We then explored its functional roles using various functional assays in a rat model after SCI.<h4>Results</h4>We found that rno-circRNA-013017-the selected target circRNA-reduced neuron apoptosis, preserved the survival and activity of motor neurons, and regulated apoptosis-related proteins at 3 days post-SCI using western blot, immunofluorescence and polymerase chain rea","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-29T20:13:51.921Z","creation":"2025-04-07T10:14:07.539Z"},"accession":"S-EPMC9797719","cross_references":{"pubmed":["36590290"],"doi":["10.3389/fnins.2022.1065897"]}}