{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Moored KD"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","National Center for Advancing Translational Sciences","NIH Roadmap for Medical Research","NCATS NIH HHS","NIA NIH HHS","NIAMS NIH HHS","Claude D. Pepper Older Americans Independence Center, Research Registry and Developmental Pilot","National Institute on Aging"],"pagination":["2498-2506"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9799181"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["77(12)"],"pubmed_abstract":["<h4>Background</h4>Lower physical activity has been cross-sectionally associated with greater perceived fatigability, defined as self-reported fatigue anchored to activity intensity and duration. The temporality of this relationship, and whether it differs by activity type or marital status, remains unclear.<h4>Methods</h4>In the Osteoporotic Fractures in Men Study (N = 1 759), self-reported total, exercise, and household activity were assessed using the Physical Activity Scale for the Elderly across 7 visits (2000-2016). The Pittsburgh Fatigability Scale (range: 0-50; higher scores = greater fatigability) measured physical (mean = 16.6 ± 9.7) and mental (mean = 7.8 ± 8.3) fatigability at Year 14. Least absolute deviation and linear regression were used to examine associations between baseline and change in activity over 14 years with subsequent fatigability. Models were adjusted for demographic, health, and lifestyle factors.<h4>Results</h4>After adjustment, lower baseline (β= -0.08, 95% confidence interval [CI]: -0.12, -0.04) and greater annual declines in total activity (β = -0.09, 95% CI: -0.14, -0.05) were prospectively associated with higher Pittsburgh Fatigability Scale (PFS) Physical scores. Associations were similar for mental fatigability (both p < .05). Lower baseline leisure exercise, but not baseline household activity, predicted higher PFS Physical scores (β = -0.10 vs -0.001). In contrast, greater declines in household activity, but not declines in exercise, were associated with higher PFS Physical scores (β = -0.09 vs -0.03). Lower baseline household activity predicted higher PFS Mental scores only for unmarried men (β = -0.15, 95% CI: -0.29, -0.01, interaction p = .019).<h4>Conclusions</h4>Baseline total activity and leisure exercise, and declines in total and household activity, were associated with higher subsequent perceived fatigability in older men. Marital status may mitigate the contribution of household activity to subsequent fatigability."],"journal":["The journals of gerontology. Series A, Biological sciences and medical sciences"],"pubmed_title":["Prospective Associations Between Physical Activity and Perceived Fatigability in Older Men: Differences by Activity Type and Baseline Marital Status."],"pmcid":["PMC9799181"],"funding_grant_id":["U01 AG042139","T32 AG000181","U01 AG042124","U01 AG042168","U01 AG042145","UL1 TR000128","P30 AG024827","U01 AG042143","U01 AG027810","U01 AG042140","R01 AG066671","U01 AR066160","R56 AG061085"],"pubmed_authors":["Moored KD","Roe LS","Cauley JA","Glynn NW","Qiao YS","Cawthon PM","Boudreau RM"],"additional_accession":[]},"is_claimable":false,"name":"Prospective Associations Between Physical Activity and Perceived Fatigability in Older Men: Differences by Activity Type and Baseline Marital Status.","description":"<h4>Background</h4>Lower physical activity has been cross-sectionally associated with greater perceived fatigability, defined as self-reported fatigue anchored to activity intensity and duration. The temporality of this relationship, and whether it differs by activity type or marital status, remains unclear.<h4>Methods</h4>In the Osteoporotic Fractures in Men Study (N = 1 759), self-reported total, exercise, and household activity were assessed using the Physical Activity Scale for the Elderly across 7 visits (2000-2016). The Pittsburgh Fatigability Scale (range: 0-50; higher scores = greater fatigability) measured physical (mean = 16.6 ± 9.7) and mental (mean = 7.8 ± 8.3) fatigability at Year 14. Least absolute deviation and linear regression were used to examine associations between baseline and change in activity over 14 years with subsequent fatigability. Models were adjusted for demographic, health, and lifestyle factors.<h4>Results</h4>After adjustment, lower baseline (β= -0.08, 95% confidence interval [CI]: -0.12, -0.04) and greater annual declines in total activity (β = -0.09, 95% CI: -0.14, -0.05) were prospectively associated with higher Pittsburgh Fatigability Scale (PFS) Physical scores. Associations were similar for mental fatigability (both p < .05). Lower baseline leisure exercise, but not baseline household activity, predicted higher PFS Physical scores (β = -0.10 vs -0.001). In contrast, greater declines in household activity, but not declines in exercise, were associated with higher PFS Physical scores (β = -0.09 vs -0.03). Lower baseline household activity predicted higher PFS Mental scores only for unmarried men (β = -0.15, 95% CI: -0.29, -0.01, interaction p = .019).<h4>Conclusions</h4>Baseline total activity and leisure exercise, and declines in total and household activity, were associated with higher subsequent perceived fatigability in older men. Marital status may mitigate the contribution of household activity to subsequent fatigability.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-26T18:03:59.667Z","creation":"2025-04-06T15:43:45.396Z"},"accession":"S-EPMC9799181","cross_references":{"pubmed":["35134905"],"doi":["10.1093/gerona/glac030"]}}