{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Eastlack M"],"funding":["NIA NIH HHS","RRD VA","National Institute on Aging"],"pagination":["2445-2452"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9799201"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["77(12)"],"pubmed_abstract":["<h4>Background</h4>Computed tomography (CT)-scan measures of muscle composition may be associated with recovery post hip fracture.<h4>Methods</h4>In an ancillary study to Baltimore Hip Studies Seventh cohort, older adults were evaluated at 2 and 6 months post hip fracture. CT-scan measures of muscle were acquired at 2 months. Short Physical Performance Battery (SPPB) was measured at 2 and 6 months. Generalized estimating equations were used to model the association of muscle measures and physical function, adjusting for age, sex, body mass index, and time postfracture.<h4>Results</h4>Seventy-one older adults (52% males, age 79.6 ± 7.3 years) were included. At 2-months, males had greater thigh cross-sectional area (CSA, p < .0001) and less low-density muscle (p = .047), and intermuscular adipose tissue (p = .007) than females on the side of the fracture, while females performed better on the SPPB (p = .05). Muscle measures on the fractured side were associated with function at 2 months in both sexes. Participants with the lowest tertile of muscle CSA difference at 2-months, indicating greater symmetry in CSA between limbs, performed better than the other 2 tertiles at 6-months. Males performed worse in functional measures at baseline and did not recover as well as females (p = .02).<h4>Conclusion</h4>CT-scan measures of muscle CSA and fatty infiltration were associated with function at 2-months post hip fracture and with improvement in function by 6 months. Observed sex differences in these associations suggest that rehabilitation strategies may need to be adapted by sex after hip fracture."],"journal":["The journals of gerontology. Series A, Biological sciences and medical sciences"],"pubmed_title":["Thigh Muscle Composition and Its Relationship to Functional Recovery Post Hip Fracture Over Time and Between Sexes."],"pmcid":["PMC9799201"],"funding_grant_id":["P30-AG028747","T32 AG00262","IK6 RX003977","R37 AG009901","T32 AG000262","R01 AG029315","P30 AG028747","R37 AG09901"],"pubmed_authors":["Eastlack M","Magaziner J","Miller RR","Gruber-Baldini A","Orwig DL","Ryan AS","Hicks GE"],"additional_accession":[]},"is_claimable":false,"name":"Thigh Muscle Composition and Its Relationship to Functional Recovery Post Hip Fracture Over Time and Between Sexes.","description":"<h4>Background</h4>Computed tomography (CT)-scan measures of muscle composition may be associated with recovery post hip fracture.<h4>Methods</h4>In an ancillary study to Baltimore Hip Studies Seventh cohort, older adults were evaluated at 2 and 6 months post hip fracture. CT-scan measures of muscle were acquired at 2 months. Short Physical Performance Battery (SPPB) was measured at 2 and 6 months. Generalized estimating equations were used to model the association of muscle measures and physical function, adjusting for age, sex, body mass index, and time postfracture.<h4>Results</h4>Seventy-one older adults (52% males, age 79.6 ± 7.3 years) were included. At 2-months, males had greater thigh cross-sectional area (CSA, p < .0001) and less low-density muscle (p = .047), and intermuscular adipose tissue (p = .007) than females on the side of the fracture, while females performed better on the SPPB (p = .05). Muscle measures on the fractured side were associated with function at 2 months in both sexes. Participants with the lowest tertile of muscle CSA difference at 2-months, indicating greater symmetry in CSA between limbs, performed better than the other 2 tertiles at 6-months. Males performed worse in functional measures at baseline and did not recover as well as females (p = .02).<h4>Conclusion</h4>CT-scan measures of muscle CSA and fatty infiltration were associated with function at 2-months post hip fracture and with improvement in function by 6 months. Observed sex differences in these associations suggest that rehabilitation strategies may need to be adapted by sex after hip fracture.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-06-04T05:49:00.005Z","creation":"2025-04-19T13:29:57.732Z"},"accession":"S-EPMC9799201","cross_references":{"pubmed":["35580856"],"doi":["10.1093/gerona/glac112"]}}