biostudies-literatureEastlack MNIA NIH HHSRRD VANational Institute on Aging2445-2452https://www.ebi.ac.uk/biostudies/studies/S-EPMC9799201biostudies-literatureUnknown77(12)<h4>Background</h4>Computed tomography (CT)-scan measures of muscle composition may be associated with recovery post hip fracture.<h4>Methods</h4>In an ancillary study to Baltimore Hip Studies Seventh cohort, older adults were evaluated at 2 and 6 months post hip fracture. CT-scan measures of muscle were acquired at 2 months. Short Physical Performance Battery (SPPB) was measured at 2 and 6 months. Generalized estimating equations were used to model the association of muscle measures and physical function, adjusting for age, sex, body mass index, and time postfracture.<h4>Results</h4>Seventy-one older adults (52% males, age 79.6 ± 7.3 years) were included. At 2-months, males had greater thigh cross-sectional area (CSA, p < .0001) and less low-density muscle (p = .047), and intermuscular adipose tissue (p = .007) than females on the side of the fracture, while females performed better on the SPPB (p = .05). Muscle measures on the fractured side were associated with function at 2 months in both sexes. Participants with the lowest tertile of muscle CSA difference at 2-months, indicating greater symmetry in CSA between limbs, performed better than the other 2 tertiles at 6-months. Males performed worse in functional measures at baseline and did not recover as well as females (p = .02).<h4>Conclusion</h4>CT-scan measures of muscle CSA and fatty infiltration were associated with function at 2-months post hip fracture and with improvement in function by 6 months. Observed sex differences in these associations suggest that rehabilitation strategies may need to be adapted by sex after hip fracture.The journals of gerontology. Series A, Biological sciences and medical sciencesThigh Muscle Composition and Its Relationship to Functional Recovery Post Hip Fracture Over Time and Between Sexes.PMC9799201P30-AG028747T32 AG00262IK6 RX003977R37 AG009901T32 AG000262R01 AG029315P30 AG028747R37 AG09901Eastlack MMagaziner JMiller RRGruber-Baldini AOrwig DLRyan ASHicks GEfalseThigh Muscle Composition and Its Relationship to Functional Recovery Post Hip Fracture Over Time and Between Sexes.<h4>Background</h4>Computed tomography (CT)-scan measures of muscle composition may be associated with recovery post hip fracture.<h4>Methods</h4>In an ancillary study to Baltimore Hip Studies Seventh cohort, older adults were evaluated at 2 and 6 months post hip fracture. CT-scan measures of muscle were acquired at 2 months. Short Physical Performance Battery (SPPB) was measured at 2 and 6 months. Generalized estimating equations were used to model the association of muscle measures and physical function, adjusting for age, sex, body mass index, and time postfracture.<h4>Results</h4>Seventy-one older adults (52% males, age 79.6 ± 7.3 years) were included. At 2-months, males had greater thigh cross-sectional area (CSA, p < .0001) and less low-density muscle (p = .047), and intermuscular adipose tissue (p = .007) than females on the side of the fracture, while females performed better on the SPPB (p = .05). Muscle measures on the fractured side were associated with function at 2 months in both sexes. Participants with the lowest tertile of muscle CSA difference at 2-months, indicating greater symmetry in CSA between limbs, performed better than the other 2 tertiles at 6-months. Males performed worse in functional measures at baseline and did not recover as well as females (p = .02).<h4>Conclusion</h4>CT-scan measures of muscle CSA and fatty infiltration were associated with function at 2-months post hip fracture and with improvement in function by 6 months. Observed sex differences in these associations suggest that rehabilitation strategies may need to be adapted by sex after hip fracture.2022-01-01T00:00:00Z2022 Dec2026-06-04T05:49:00.005Z2025-04-19T13:29:57.732ZS-EPMC97992013558085610.1093/gerona/glac112