{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Joyce BT"],"funding":["Intramural NIH HHS","NIA NIH HHS","American Heart Association-American Stroke Association","University of Alabama at Birmingham","NHLBI NIH HHS","Kaiser Foundation Research Institute","National Heart, Lung, and Blood Institute","University of Minnesota","Northwestern University","Intramural Research Program","National Institute on Aging"],"pagination":["2517-2523"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9799217"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["77(12)"],"pubmed_abstract":["<h4>Background</h4>Studies found associations between pulmonary function (PF) and cognition, but these are limited by mostly cross-sectional design and a single measure of PF (typically forced expiratory volume in 1 second [FEV1]). Our objective was to prospectively analyze the association of repeatedly measured PF with cognition.<h4>Methods</h4>We studied 3 499 participants in the Coronary Artery Risk Development in Young Adults cohort with cognition measured at year 25 (Y25) and Y30, and PF (FEV1 and forced vital capacity [FVC], reflecting better PF) measured up to 6 times from Y0 to Y20. Cognition was measured via Stroop test, Rey-Auditory Verbal Learning Test [RAVLT], and digit symbol substitution test [DSST], which capture executive function, verbal learning and memory, and attention and psychomotor speed, respectively; lower Stroop, and higher RAVLT and DSST scores indicate better cognition. We modeled linear, cross-sectional associations between cognition and PF at Y30 (mean age 55), and mixed models to examine associations between cognition at Y25-Y30 and longitudinal PF (both annual rate of change, and cumulative PF from Y0 to Y20).<h4>Results</h4>At Y30, FEV1 and FVC were cross-sectionally associated with all 3 measures of cognition (β = 0.08-0.12, p < .01-.02). Annual change from peak FEV1/FVC ratio was associated with Stroop and DSST (β = 18.06, 95% CI = 7.71-28.40; β = 10.30, 95% CI = 0.26-20.34, respectively), but not RAVLT. Cumulative FEV1 and FVC were associated with Stroop and DSST (β = 0.07-0.12, p < .01-.02), but only cumulative FEV1 was associated with RAVLT (β = 0.07, 95% CI = 0.00-0.14).<h4>Conclusions</h4>We identified prospective associations between measures of PF and cognition even at middle ages, adding evidence of a prospective association between reduced PF and cognitive decline."],"journal":["The journals of gerontology. Series A, Biological sciences and medical sciences"],"pubmed_title":["Pulmonary Function in Midlife as a Predictor of Later-Life Cognition: The Coronary Artery Risk Development in Adults (CARDIA) Study."],"pmcid":["PMC9799217"],"funding_grant_id":["HHSN268201800005I","HHSN268201800004I","AG0005","HHSN268201800007I","HHSN268201800006I","HHSN268201800003I","19CDA34630050","R01 HL122477"],"pubmed_authors":["Washko G","Zheng Y","Liu K","Gross M","Henkle BE","Kunisaki KM","Hou L","Thyagarajan B","Lloyd-Jones D","Yaffe K","Sidney S","Kalhan R","Joyce BT","Chen X","Jacobs DR","Gao T"],"additional_accession":[]},"is_claimable":false,"name":"Pulmonary Function in Midlife as a Predictor of Later-Life Cognition: The Coronary Artery Risk Development in Adults (CARDIA) Study.","description":"<h4>Background</h4>Studies found associations between pulmonary function (PF) and cognition, but these are limited by mostly cross-sectional design and a single measure of PF (typically forced expiratory volume in 1 second [FEV1]). Our objective was to prospectively analyze the association of repeatedly measured PF with cognition.<h4>Methods</h4>We studied 3 499 participants in the Coronary Artery Risk Development in Young Adults cohort with cognition measured at year 25 (Y25) and Y30, and PF (FEV1 and forced vital capacity [FVC], reflecting better PF) measured up to 6 times from Y0 to Y20. Cognition was measured via Stroop test, Rey-Auditory Verbal Learning Test [RAVLT], and digit symbol substitution test [DSST], which capture executive function, verbal learning and memory, and attention and psychomotor speed, respectively; lower Stroop, and higher RAVLT and DSST scores indicate better cognition. We modeled linear, cross-sectional associations between cognition and PF at Y30 (mean age 55), and mixed models to examine associations between cognition at Y25-Y30 and longitudinal PF (both annual rate of change, and cumulative PF from Y0 to Y20).<h4>Results</h4>At Y30, FEV1 and FVC were cross-sectionally associated with all 3 measures of cognition (β = 0.08-0.12, p < .01-.02). Annual change from peak FEV1/FVC ratio was associated with Stroop and DSST (β = 18.06, 95% CI = 7.71-28.40; β = 10.30, 95% CI = 0.26-20.34, respectively), but not RAVLT. Cumulative FEV1 and FVC were associated with Stroop and DSST (β = 0.07-0.12, p < .01-.02), but only cumulative FEV1 was associated with RAVLT (β = 0.07, 95% CI = 0.00-0.14).<h4>Conclusions</h4>We identified prospective associations between measures of PF and cognition even at middle ages, adding evidence of a prospective association between reduced PF and cognitive decline.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-19T17:57:41.346Z","creation":"2025-04-19T17:57:41.346Z"},"accession":"S-EPMC9799217","cross_references":{"pubmed":["35106576"],"doi":["10.1093/gerona/glac026"]}}