{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(6)"],"submitter":["Shao Q"],"pubmed_abstract":["Liposomes have been widely investigated as a class of promising antibiotic delivery systems for the treatment of life-threatening bacterial infections. However, the inevitable formation of protein corona on the liposomal surface can heavily impact <i>in vivo</i> performance. A better understanding of the effects of protein corona on liposomal behavior can significantly improve antibacterial liposomal drug development. Here, the critical role of protein corona in mediating liposome-bacteria interactions was elucidated. Adsorption of negatively charged protein on cationic liposome weakened electrostatic attraction-enhanced liposomal binding to the bacteria. Cumulative complement deposition on anionic liposome composed of phosphatidylglycerol (DSPG sLip) contributed to a superior binding affinity of DSPG sLip to planktonic bacteria and biofilms, which was exploited to enhance bacteria-targeted drug delivery. In both <i>S. aureus</i>-related osteomyelitis and pneumonia mice models, DSPG sLip was demonstrated as a promising antibiotic nanocarrier for managing MRSA infection, indicating the benefits of lipid composition-based protein corona modulation in liposomal antibiotic delivery for bacterial infection treatment."],"journal":["Asian journal of pharmaceutical sciences"],"pagination":["855-866"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9800951"],"repository":["biostudies-literature"],"pubmed_title":["Protein corona mediated liposomal drug delivery for bacterial infection management."],"pmcid":["PMC9800951"],"pubmed_authors":["Li G","Qian J","Zhan C","Ding T","Pan F","Shen S","Wei X","Shao Q"],"additional_accession":[]},"is_claimable":false,"name":"Protein corona mediated liposomal drug delivery for bacterial infection management.","description":"Liposomes have been widely investigated as a class of promising antibiotic delivery systems for the treatment of life-threatening bacterial infections. However, the inevitable formation of protein corona on the liposomal surface can heavily impact <i>in vivo</i> performance. A better understanding of the effects of protein corona on liposomal behavior can significantly improve antibacterial liposomal drug development. Here, the critical role of protein corona in mediating liposome-bacteria interactions was elucidated. Adsorption of negatively charged protein on cationic liposome weakened electrostatic attraction-enhanced liposomal binding to the bacteria. Cumulative complement deposition on anionic liposome composed of phosphatidylglycerol (DSPG sLip) contributed to a superior binding affinity of DSPG sLip to planktonic bacteria and biofilms, which was exploited to enhance bacteria-targeted drug delivery. In both <i>S. aureus</i>-related osteomyelitis and pneumonia mice models, DSPG sLip was demonstrated as a promising antibiotic nanocarrier for managing MRSA infection, indicating the benefits of lipid composition-based protein corona modulation in liposomal antibiotic delivery for bacterial infection treatment.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T21:04:44.527Z","creation":"2025-04-04T21:04:44.527Z"},"accession":"S-EPMC9800951","cross_references":{"pubmed":["36600900"],"doi":["10.1016/j.ajps.2022.10.003"]}}