{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Jamieson WRE"],"funding":["Artivion Inc"],"pubmed_abstract":["Objectives
The Prospective Randomized On-X Mechanical Prosthesis Versus St Jude Medical Mechanical Prosthesis Evaluation (PROSE) trial purpose was to investigate whether a current-generation mechanical prosthesis (On-X; On-X Life Technologies/Artivion Inc) reduced the incidence of thromboembolic-related complications compared with a previous-generation mechanical prosthesis (St Jude Medical Mechanical Prosthesis; Abbott/St Jude Medical). This second report documents the valve-related complications by individual prostheses and by Western and Developing populations.Methods
The PROSE trial study was conducted in 28 worldwide centers and incorporated 855 subjects randomized between 2003 and 2016. The study enrollment was discontinued on August 31, 2016. The study protocol, and "],"journal":["JTCVS open"],"pagination":["51-70"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9801238"],"repository":["biostudies-literature"],"pubmed_title":["PROSE: Prospective Randomized Trial of the On-X Mechanical Prosthesis and the St Jude Medical Mechanical Prosthesis Evaluation: Part 2: Study results-prostheses, positions, and economic development."],"pmcid":["PMC9801238"],"pubmed_authors":["Langlois Y","Siepe M","Sridhar V","Cherian KM","Jamieson WRE","Pfeffer TA","Fedoruk LM","Mohan Rao PS","Nair S","Brown C","Chen JC","Pennel T","Haaverstad R","Scholz PM","Geisner T","Patel J","Munfakh NA","Wiklund L","Schlensak C","Kappetein AP","Doenst T","Damiano RJ","Bannon P","Gupta RK","Agrawal D","Ely JL","Bavaria JE","Azar H","Brink J","Ye J"],"additional_accession":[]},"is_claimable":false,"name":"PROSE: Prospective Randomized Trial of the On-X Mechanical Prosthesis and the St Jude Medical Mechanical Prosthesis Evaluation: Part 2: Study results-prostheses, positions, and economic development.","description":"Objectives
The Prospective Randomized On-X Mechanical Prosthesis Versus St Jude Medical Mechanical Prosthesis Evaluation (PROSE) trial purpose was to investigate whether a current-generation mechanical prosthesis (On-X; On-X Life Technologies/Artivion Inc) reduced the incidence of thromboembolic-related complications compared with a previous-generation mechanical prosthesis (St Jude Medical Mechanical Prosthesis; Abbott/St Jude Medical). This second report documents the valve-related complications by individual prostheses and by Western and Developing populations.Methods
The PROSE trial study was conducted in 28 worldwide centers and incorporated 855 subjects randomized between 2003 and 2016. The study enrollment was discontinued on August 31, 2016. The study protocol, and ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-22T10:11:21.993Z","creation":"2025-04-05T23:27:39.839Z"},"accession":"S-EPMC9801238","cross_references":{"pubmed":["36590733"],"doi":["10.1016/j.xjon.2022.07.011"]}}