{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Kyo S"],"pubmed_abstract":["<h4>Objectives</h4>Acute kidney injury is a serious complication after cardiovascular surgery requiring circulatory arrest. It is reported that mice can be induced into a hibernation-like hypometabolic state by stimulating a specific neuron located at the hypothalamus (quiescence-inducing neurons-induced hypometabolism [QIH]). Here, we investigated the efficacy of QIH for the amelioration of acute kidney injury in an experimental circulatory arrest using a transgenic mouse model.<h4>Methods</h4>We genetically prepared mice in which QIH can be conditionally induced (QIH-ready mice). Mice were divided into 4 groups (n = 6 for each): QIH-ready normothermia (QN), QIH-ready hypothermia (QH), control normothermia (CN), and control hypothermia (CH). After induction of QIH, left thoracotomy and de"],"journal":["JTCVS open"],"pagination":["201-210"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9801336"],"repository":["biostudies-literature"],"pubmed_title":["Quiescence-inducing neurons-induced hypometabolism ameliorates acute kidney injury in a mouse model mimicking cardiovascular surgery requiring circulatory arrest."],"pmcid":["PMC9801336"],"pubmed_authors":["Minatoya K","Sunagawa GA","Masumoto H","Murata K","Kawatou M","Kyo S"],"additional_accession":[]},"is_claimable":false,"name":"Quiescence-inducing neurons-induced hypometabolism ameliorates acute kidney injury in a mouse model mimicking cardiovascular surgery requiring circulatory arrest.","description":"<h4>Objectives</h4>Acute kidney injury is a serious complication after cardiovascular surgery requiring circulatory arrest. It is reported that mice can be induced into a hibernation-like hypometabolic state by stimulating a specific neuron located at the hypothalamus (quiescence-inducing neurons-induced hypometabolism [QIH]). Here, we investigated the efficacy of QIH for the amelioration of acute kidney injury in an experimental circulatory arrest using a transgenic mouse model.<h4>Methods</h4>We genetically prepared mice in which QIH can be conditionally induced (QIH-ready mice). Mice were divided into 4 groups (n = 6 for each): QIH-ready normothermia (QN), QIH-ready hypothermia (QH), control normothermia (CN), and control hypothermia (CH). After induction of QIH, left thoracotomy and de","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-05T12:43:36.114Z","creation":"2025-04-05T12:43:36.114Z"},"accession":"S-EPMC9801336","cross_references":{"pubmed":["36590714"],"doi":["10.1016/j.xjon.2022.11.001"]}}