biostudies-literatureZimbalist ASAmerican Institute for Cancer ResearchNCI NIH HHSNational Cancer Institute, United States1361https://www.ebi.ac.uk/biostudies/studies/S-EPMC9801571biostudies-literatureUnknown22(1)Research on the impact of metabolic abnormalities on breast cancer prognosis is limited by small samples and assessment of laboratory values at a single time point, often prior to cancer diagnosis and treatment. In this population-based cohort, time-updated laboratory values were adjusted for cancer treatment to assess the association between metabolic risk factors (glucose, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides) and breast cancer survival. 13,434 women diagnosed with stage I-III breast cancer from 2005-15 at Kaiser Permanente were included. All outpatient fasting glucose, HDL-C, LDL-C, and triglyceride values from diagnosis through 2019 or death were extracted from electronic medical records. Risk of breast cancer-specificBMC cancerMetabolic abnormalities and survival among patients with non-metastatic breast cancer.PMC9801571632996R01 CA251589R01CA251589Dillon DARZimbalist ASMittendorf EAQuesenberry CCespedes Feliciano EMCaan BJChen WYfalseMetabolic abnormalities and survival among patients with non-metastatic breast cancer.Research on the impact of metabolic abnormalities on breast cancer prognosis is limited by small samples and assessment of laboratory values at a single time point, often prior to cancer diagnosis and treatment. In this population-based cohort, time-updated laboratory values were adjusted for cancer treatment to assess the association between metabolic risk factors (glucose, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides) and breast cancer survival. 13,434 women diagnosed with stage I-III breast cancer from 2005-15 at Kaiser Permanente were included. All outpatient fasting glucose, HDL-C, LDL-C, and triglyceride values from diagnosis through 2019 or death were extracted from electronic medical records. Risk of breast cancer-specific2022-01-01T00:00:00Z2022 Dec2025-05-29T16:21:57.776Z2025-04-19T18:09:34.067ZS-EPMC98015713658181710.1186/s12885-022-10430-9