{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sasamoto N"],"funding":["NIH","Department of Defense"],"pagination":["2042-2053"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9801982"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["37(9)"],"pubmed_abstract":["<h4>Study question</h4>What are the systemic molecular profiles of endometriosis diagnosed in adolescents and young adults?<h4>Summary answer</h4>Significant enrichment and increased activation of proteins related to angiogenesis and cell migration pathways were observed in endometriosis cases compared to controls (P-value < 2.4 × 10-8).<h4>What is known already</h4>Little is known about the pathophysiology of adolescent endometriosis despite the fact that over 50% of adults with endometriosis report onset of severe pelvic pain during adolescence.<h4>Study design, size, duration</h4>A cross-sectional analysis using data on 142 laparoscopically confirmed endometriosis cases and 74 controls from the observational longitudinal cohort of Women's Health Study: From Adolescence to Adulthood (A2A"],"journal":["Human reproduction (Oxford, England)"],"pubmed_title":["Circulating proteomic profiles associated with endometriosis in adolescents and young adults."],"pmcid":["PMC9801982"],"funding_grant_id":["W81XWH1910318"],"pubmed_authors":["Vitonis AF","Missmer SA","Sasamoto N","Terry KL","Ngo L","Libermann TA","Dillon ST"],"additional_accession":[]},"is_claimable":false,"name":"Circulating proteomic profiles associated with endometriosis in adolescents and young adults.","description":"<h4>Study question</h4>What are the systemic molecular profiles of endometriosis diagnosed in adolescents and young adults?<h4>Summary answer</h4>Significant enrichment and increased activation of proteins related to angiogenesis and cell migration pathways were observed in endometriosis cases compared to controls (P-value < 2.4 × 10-8).<h4>What is known already</h4>Little is known about the pathophysiology of adolescent endometriosis despite the fact that over 50% of adults with endometriosis report onset of severe pelvic pain during adolescence.<h4>Study design, size, duration</h4>A cross-sectional analysis using data on 142 laparoscopically confirmed endometriosis cases and 74 controls from the observational longitudinal cohort of Women's Health Study: From Adolescence to Adulthood (A2A","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-05T12:09:22.281Z","creation":"2025-04-05T12:09:22.281Z"},"accession":"S-EPMC9801982","cross_references":{"pubmed":["35770801"],"doi":["10.1093/humrep/deac146"]}}