biostudies-literatureSasamoto NNIHDepartment of Defense2042-2053https://www.ebi.ac.uk/biostudies/studies/S-EPMC9801982biostudies-literatureUnknown37(9)<h4>Study question</h4>What are the systemic molecular profiles of endometriosis diagnosed in adolescents and young adults?<h4>Summary answer</h4>Significant enrichment and increased activation of proteins related to angiogenesis and cell migration pathways were observed in endometriosis cases compared to controls (P-value < 2.4 × 10-8).<h4>What is known already</h4>Little is known about the pathophysiology of adolescent endometriosis despite the fact that over 50% of adults with endometriosis report onset of severe pelvic pain during adolescence.<h4>Study design, size, duration</h4>A cross-sectional analysis using data on 142 laparoscopically confirmed endometriosis cases and 74 controls from the observational longitudinal cohort of Women's Health Study: From Adolescence to Adulthood (A2AHuman reproduction (Oxford, England)Circulating proteomic profiles associated with endometriosis in adolescents and young adults.PMC9801982W81XWH1910318Vitonis AFMissmer SASasamoto NTerry KLNgo LLibermann TADillon STfalseCirculating proteomic profiles associated with endometriosis in adolescents and young adults.<h4>Study question</h4>What are the systemic molecular profiles of endometriosis diagnosed in adolescents and young adults?<h4>Summary answer</h4>Significant enrichment and increased activation of proteins related to angiogenesis and cell migration pathways were observed in endometriosis cases compared to controls (P-value < 2.4 × 10-8).<h4>What is known already</h4>Little is known about the pathophysiology of adolescent endometriosis despite the fact that over 50% of adults with endometriosis report onset of severe pelvic pain during adolescence.<h4>Study design, size, duration</h4>A cross-sectional analysis using data on 142 laparoscopically confirmed endometriosis cases and 74 controls from the observational longitudinal cohort of Women's Health Study: From Adolescence to Adulthood (A2A2022-01-01T00:00:00Z2022 Aug2025-04-05T12:09:22.281Z2025-04-05T12:09:22.281ZS-EPMC98019823577080110.1093/humrep/deac146