{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Toribio M"],"funding":["Hassenfeld Scholar Award","Michael and Kathryn Park Chair","National Center for Research Resources","NICHD NIH HHS","NIH/NHLBI","NIAID NIH HHS","NHLBI NIH HHS","A. Curt Greer and Pamela Kohlberg","NIH/ National Heart, Lung, and Blood Institute","NIH/NIAID","National Research, Development, and Innovation Fund","NIH/Harvard Center for AIDS Research","Nutrition Obesity Research Center","NIH/National Institute of Child Health and Human Development","Robert Wood Johnson Foundation","Paul and Christina Kasolinas"],"pagination":["e0279913"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9803182"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(12)"],"pubmed_abstract":["<h4>Background</h4>Women with HIV (WWH) face heightened risks of heart failure; however, insights on immune/inflammatory pathways potentially contributing to left ventricular (LV) systolic dysfunction among WWH remain limited.<h4>Setting</h4>Massachusetts General Hospital, Boston, Massachusetts.<h4>Methods</h4>Global longitudinal strain (GLS) is a sensitive measure of LV systolic function, with lower cardiac strain predicting incident heart failure and adverse heart failure outcomes. We analyzed relationships between GLS (cardiovascular magnetic resonance imaging) and monocyte activation (flow cytometry) among 20 WWH and 14 women without HIV.<h4>Results</h4>WWH had lower GLS compared to women without HIV (WWH vs. women without HIV: 19.4±3.0 vs. 23.1±1.9%, P<0.0001). Among the whole group, "],"journal":["PloS one"],"pubmed_title":["Cardiac strain is lower among women with HIV in relation to monocyte activation."],"pmcid":["PMC9803182"],"funding_grant_id":["P30AI060354","R01HL141132","ÚNKP-22-4-II-SE","5K23HD100266-03","R01 HL130539","K23 HD100266","8 UL 1TR000170 and 1 UL 1TR001102","P30 AI060354","K23 HL147799","R01 HL137562","DK040561","1K23HL147799-01","1K24AI157882","R01 HL146267","R01HL137562, R01HL130539, and K24HL150238","R01 HL141132","R01HL137562 and R01HL146267","K24 HL150238","K24 AI157882"],"pubmed_authors":["Alagpulinsa DA","Toribio M","Stanley TL","Awadalla M","Nelson MD","Longenecker CT","Burdo TH","Quinaglia T","Durbin CG","Drobni ZD","Fourman LT","Wang M","Suero-Abreu GA","Zanni MV","Neilan TG"],"additional_accession":[]},"is_claimable":false,"name":"Cardiac strain is lower among women with HIV in relation to monocyte activation.","description":"<h4>Background</h4>Women with HIV (WWH) face heightened risks of heart failure; however, insights on immune/inflammatory pathways potentially contributing to left ventricular (LV) systolic dysfunction among WWH remain limited.<h4>Setting</h4>Massachusetts General Hospital, Boston, Massachusetts.<h4>Methods</h4>Global longitudinal strain (GLS) is a sensitive measure of LV systolic function, with lower cardiac strain predicting incident heart failure and adverse heart failure outcomes. We analyzed relationships between GLS (cardiovascular magnetic resonance imaging) and monocyte activation (flow cytometry) among 20 WWH and 14 women without HIV.<h4>Results</h4>WWH had lower GLS compared to women without HIV (WWH vs. women without HIV: 19.4±3.0 vs. 23.1±1.9%, P<0.0001). Among the whole group, ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-07-14T17:02:14.859Z","creation":"2025-02-18T22:34:30.732Z"},"accession":"S-EPMC9803182","cross_references":{"pubmed":["36584183"],"doi":["10.1371/journal.pone.0279913"]}}