{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Millman ZB"],"funding":["U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)","Andrew P. Merrill Memorial Research Fellowship Joseph &amp; Susan Gatto Foundation","U.S. Department of Health &amp; Human Services | NIH | National Institute of Mental Health"],"pagination":["118"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9803640"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["Childhood sexual abuse (CSA) is a potentially unique risk factor for auditory hallucinations (AH), but few studies have examined the moderating effects of sex or the association of CSA with limbic gray matter volume (GMV) in transdiagnostic samples of people with psychotic disorders. Here we found that people with psychotic disorders reported higher levels of all surveyed maltreatment types (e.g., physical abuse) than healthy controls, but people with psychotic disorders with AH (n = 41) reported greater CSA compared to both those without AH (n = 37; t = -2.21, p = .03) and controls (n = 37; t = -3.90, p < .001). Among people with psychosis, elevated CSA was most pronounced among females with AH (sex × AH status: F = 4.91, p = .009), held controlling for diagnosis, medications, and other m"],"journal":["Schizophrenia (Heidelberg, Germany)"],"pubmed_title":["Auditory hallucinations, childhood sexual abuse, and limbic gray matter volume in a transdiagnostic sample of people with psychosis."],"pmcid":["PMC9803640"],"funding_grant_id":["K23MH100611","R01MH112748","T32MH016259","P50MH115846"],"pubmed_authors":["Shinn AK","Shenton ME","Hwang M","Sydnor VJ","Goldenberg JE","Millman ZB","Ongur D","Reid BE","Talero JN","Bouix S"],"additional_accession":[]},"is_claimable":false,"name":"Auditory hallucinations, childhood sexual abuse, and limbic gray matter volume in a transdiagnostic sample of people with psychosis.","description":"Childhood sexual abuse (CSA) is a potentially unique risk factor for auditory hallucinations (AH), but few studies have examined the moderating effects of sex or the association of CSA with limbic gray matter volume (GMV) in transdiagnostic samples of people with psychotic disorders. Here we found that people with psychotic disorders reported higher levels of all surveyed maltreatment types (e.g., physical abuse) than healthy controls, but people with psychotic disorders with AH (n = 41) reported greater CSA compared to both those without AH (n = 37; t = -2.21, p = .03) and controls (n = 37; t = -3.90, p < .001). Among people with psychosis, elevated CSA was most pronounced among females with AH (sex × AH status: F = 4.91, p = .009), held controlling for diagnosis, medications, and other m","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-05-29T16:22:00.15Z","creation":"2025-05-29T16:22:00.15Z"},"accession":"S-EPMC9803640","cross_references":{"pubmed":["36585407"],"doi":["10.1038/s41537-022-00323-y"]}}