biostudies-literatureArrestier RNCRR NIH HHSNIAID NIH HHS121https://www.ebi.ac.uk/biostudies/studies/S-EPMC9803887biostudies-literatureUnknown12(1)<h4>Background</h4>Auto-antibodies (auto-Abs) neutralizing type I interferons (IFN) have been found in about 15% of critical cases COVID-19 pneumonia and less than 1% of mild or asymptomatic cases. Determining whether auto-Abs influence presentation and outcome of critically ill COVID-19 patients could lead to specific therapeutic interventions. Our objectives were to compare the severity at admission and the mortality of patients hospitalized for critical COVID-19 in ICU with versus without auto-Abs.<h4>Results</h4>We conducted a prospective multicentre cohort study including patients admitted in 11 intensive care units (ICUs) from Great Paris area hospitals with proven SARS-CoV-2 infection and acute respiratory failure. 925 critically ill COVID-19 patients were included. Auto-Abs neutralAnnals of intensive careAuto-antibodies against type I IFNs in > 10% of critically ill COVID-19 patients: a prospective multicentre study.PMC9803887R01 AI088364R01 AI163029UL1 RR024143Moncomble EBen Ahmed MParfait MBizien LGaudry SMekontso-Dessap APham TGervais AFage NBelmondo TDorgham Kde Prost NLuyt CEAzoulay EVoiriot GBastard PRoux DHue SArrestier RUrbina TCasanova JLClere-Jehl RAit-Oufella HAit-Hamou ZMayaux JCanoui-Poitrine FGorochov GSegaux LBellaiche RfalseAuto-antibodies against type I IFNs in > 10% of critically ill COVID-19 patients: a prospective multicentre study.<h4>Background</h4>Auto-antibodies (auto-Abs) neutralizing type I interferons (IFN) have been found in about 15% of critical cases COVID-19 pneumonia and less than 1% of mild or asymptomatic cases. Determining whether auto-Abs influence presentation and outcome of critically ill COVID-19 patients could lead to specific therapeutic interventions. Our objectives were to compare the severity at admission and the mortality of patients hospitalized for critical COVID-19 in ICU with versus without auto-Abs.<h4>Results</h4>We conducted a prospective multicentre cohort study including patients admitted in 11 intensive care units (ICUs) from Great Paris area hospitals with proven SARS-CoV-2 infection and acute respiratory failure. 925 critically ill COVID-19 patients were included. Auto-Abs neutral2022-01-01T00:00:00Z2022 Dec2026-07-14T16:59:02.331Z2025-04-20T00:13:12.626ZS-EPMC98038873658605010.1186/s13613-022-01095-5