{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Myren-Svelstad S"],"funding":["Norges Forskningsråd","European Research Council","Helse Midt-Norge"],"pagination":["2543-2560"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9804334"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["63(10)"],"pubmed_abstract":["<h4>Objective</h4>The switch between nonseizure and seizure states involves profound alterations in network excitability and synchrony. In this study, we aimed to identify and compare features of neural excitability and dynamics across multiple zebrafish seizure and epilepsy models.<h4>Methods</h4>Inspired by video-electroencephalographic recordings in patients, we developed a framework to study spontaneous and photically evoked neural and locomotor activity in zebrafish larvae, by combining high-throughput behavioral tracking and whole-brain in vivo two-photon calcium imaging.<h4>Results</h4>Our setup allowed us to dissect behavioral and physiological features that are divergent or convergent across multiple models. We observed that spontaneous locomotor and neural activity exhibit great "],"journal":["Epilepsia"],"pubmed_title":["Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks."],"pmcid":["PMC9804334"],"funding_grant_id":["335561","239973","90158500","314189"],"pubmed_authors":["D'gama PP","Neuhauss SCF","Jamali A","Yaksi E","Ostenrath AM","Mutlu AK","Hoffshagen HH","Hotz AL","Myren-Svelstad S","Jurisch-Yaksi N","Ophus SS"],"additional_accession":[]},"is_claimable":false,"name":"Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks.","description":"<h4>Objective</h4>The switch between nonseizure and seizure states involves profound alterations in network excitability and synchrony. In this study, we aimed to identify and compare features of neural excitability and dynamics across multiple zebrafish seizure and epilepsy models.<h4>Methods</h4>Inspired by video-electroencephalographic recordings in patients, we developed a framework to study spontaneous and photically evoked neural and locomotor activity in zebrafish larvae, by combining high-throughput behavioral tracking and whole-brain in vivo two-photon calcium imaging.<h4>Results</h4>Our setup allowed us to dissect behavioral and physiological features that are divergent or convergent across multiple models. We observed that spontaneous locomotor and neural activity exhibit great ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-05T12:09:47.696Z","creation":"2025-04-05T12:09:47.696Z"},"accession":"S-EPMC9804334","cross_references":{"pubmed":["36222083"],"doi":["10.1111/epi.17380"]}}