{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["37(11)"],"submitter":["Golfre Andreasi N"],"pubmed_abstract":["<h4>Background</h4>Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug-resistant tremor in Parkinson's disease (PD).<h4>Objective</h4>The aim of this study was to demonstrate that MRgFUS ventralis intermedius thalamotomy in early-stage tremor-dominant PD may prevent an increase in dopaminergic medication 6 months after treatment compared with matched PD control subjects on standard medical therapy.<h4>Methods</h4>We prospectively enrolled patients with early-stage PD who underwent MRgFUS ventralis intermedius thalamotomy (PD-FUS) and patients treated with oral dopaminergic therapy (PD-ODT) with a 1:2 ratio. We collected demographic and clinical data at baseline and 6 and 12 months after thalamotomy.<h4>Results</h4>We included 10 pati"],"journal":["Movement disorders : official journal of the Movement Disorder Society"],"pagination":["2289-2295"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9804690"],"repository":["biostudies-literature"],"pubmed_title":["Magnetic Resonance-Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early-Stage Tremor-Dominant Parkinson's Disease: A Pilot Study."],"pmcid":["PMC9804690"],"pubmed_authors":["Cilia R","Devigili G","Novelli A","Bruzzone MG","Straccia G","Bocchi E","Elia AE","Bonvegna S","Tringali G","Ghielmetti F","Eleopra R","Gasparini V","Piacentini SHMJ","Levi V","Prioni S","Ciceri EFM","Golfre Andreasi N","Romito LM","Messina G","Rinaldo S","Stanziano M","Amami P","Grisoli M"],"additional_accession":[]},"is_claimable":false,"name":"Magnetic Resonance-Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early-Stage Tremor-Dominant Parkinson's Disease: A Pilot Study.","description":"<h4>Background</h4>Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug-resistant tremor in Parkinson's disease (PD).<h4>Objective</h4>The aim of this study was to demonstrate that MRgFUS ventralis intermedius thalamotomy in early-stage tremor-dominant PD may prevent an increase in dopaminergic medication 6 months after treatment compared with matched PD control subjects on standard medical therapy.<h4>Methods</h4>We prospectively enrolled patients with early-stage PD who underwent MRgFUS ventralis intermedius thalamotomy (PD-FUS) and patients treated with oral dopaminergic therapy (PD-ODT) with a 1:2 ratio. We collected demographic and clinical data at baseline and 6 and 12 months after thalamotomy.<h4>Results</h4>We included 10 pati","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T19:55:29.956Z","creation":"2025-04-04T19:55:29.956Z"},"accession":"S-EPMC9804690","cross_references":{"pubmed":["36036203"],"doi":["10.1002/mds.29200"]}}