biostudies-literatureUnknown37(11)Golfre Andreasi N<h4>Background</h4>Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug-resistant tremor in Parkinson's disease (PD).<h4>Objective</h4>The aim of this study was to demonstrate that MRgFUS ventralis intermedius thalamotomy in early-stage tremor-dominant PD may prevent an increase in dopaminergic medication 6 months after treatment compared with matched PD control subjects on standard medical therapy.<h4>Methods</h4>We prospectively enrolled patients with early-stage PD who underwent MRgFUS ventralis intermedius thalamotomy (PD-FUS) and patients treated with oral dopaminergic therapy (PD-ODT) with a 1:2 ratio. We collected demographic and clinical data at baseline and 6 and 12 months after thalamotomy.<h4>Results</h4>We included 10 patiMovement disorders : official journal of the Movement Disorder Society2289-2295https://www.ebi.ac.uk/biostudies/studies/S-EPMC9804690biostudies-literatureMagnetic Resonance-Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early-Stage Tremor-Dominant Parkinson's Disease: A Pilot Study.PMC9804690Cilia RDevigili GNovelli ABruzzone MGStraccia GBocchi EElia AEBonvegna STringali GGhielmetti FEleopra RGasparini VPiacentini SHMJLevi VPrioni SCiceri EFMGolfre Andreasi NRomito LMMessina GRinaldo SStanziano MAmami PGrisoli MfalseMagnetic Resonance-Guided Focused Ultrasound Thalamotomy May Spare Dopaminergic Therapy in Early-Stage Tremor-Dominant Parkinson's Disease: A Pilot Study.<h4>Background</h4>Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug-resistant tremor in Parkinson's disease (PD).<h4>Objective</h4>The aim of this study was to demonstrate that MRgFUS ventralis intermedius thalamotomy in early-stage tremor-dominant PD may prevent an increase in dopaminergic medication 6 months after treatment compared with matched PD control subjects on standard medical therapy.<h4>Methods</h4>We prospectively enrolled patients with early-stage PD who underwent MRgFUS ventralis intermedius thalamotomy (PD-FUS) and patients treated with oral dopaminergic therapy (PD-ODT) with a 1:2 ratio. We collected demographic and clinical data at baseline and 6 and 12 months after thalamotomy.<h4>Results</h4>We included 10 pati2022-01-01T00:00:00Z2022 Nov2025-04-04T19:55:29.956Z2025-04-04T19:55:29.956ZS-EPMC98046903603620310.1002/mds.29200