biostudies-literatureUnknown28(12)Oberkofler CEThis study investigated the effect of low-dose aspirin in primary adult liver transplantation (LT) on acute cellular rejection (ACR) as well as arterial patency rates. The use of low-dose aspirin after LT is practiced by many transplant centers to minimize the risk of hepatic artery thrombosis (HAT), although solid recommendations do not exist. However, aspirin also possesses potent anti-inflammatory properties and might mitigate inflammatory processes after LT, such as rejection. Therefore, we hypothesized that the use of aspirin after LT has a protective effect against ACR. This is an international, multicenter cohort study of primary adult deceased donor LT. The study included 17 high-volume LT centers and covered the 3-year period from 2013 to 2015 to allow a minimum 5-year follow-up. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society1888-1898https://www.ebi.ac.uk/biostudies/studies/S-EPMC9804747biostudies-literatureLow-dose aspirin confers protection against acute cellular allograft rejection after primary liver transplantation.PMC9804747Busuttil RWKirchner VIto TMehrabi ASchlegel AClavien PAPetrowsky HPaladini JOberkofler CEMarques HPBauldrick FMuller PCTabrizian PLehmann KAlford SRana AGhamarnedjad OContreras AMaglione MJohnson BLodge PFlorman SSelzner MKron PParente AFernandes ESMRaptis DAPeralta PChavez-Villa MKaldas FMDutkowski POwen TJaklitsch MBasto STWinter EDi Benedetto FPollok JMFodor MHalazun KJSousa da Silva RXde Santibanes MMagistri PfalseLow-dose aspirin confers protection against acute cellular allograft rejection after primary liver transplantation.This study investigated the effect of low-dose aspirin in primary adult liver transplantation (LT) on acute cellular rejection (ACR) as well as arterial patency rates. The use of low-dose aspirin after LT is practiced by many transplant centers to minimize the risk of hepatic artery thrombosis (HAT), although solid recommendations do not exist. However, aspirin also possesses potent anti-inflammatory properties and might mitigate inflammatory processes after LT, such as rejection. Therefore, we hypothesized that the use of aspirin after LT has a protective effect against ACR. This is an international, multicenter cohort study of primary adult deceased donor LT. The study included 17 high-volume LT centers and covered the 3-year period from 2013 to 2015 to allow a minimum 5-year follow-up. 2022-01-01T00:00:00Z2022 Dec2026-05-28T03:41:36.098Z2025-04-04T20:21:06.367ZS-EPMC98047473573523210.1002/lt.26534