{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["118(4)"],"submitter":["Saldana-Ahuactzi Z"],"pubmed_abstract":["Salmonella enterica spp. produce siderophores to bind iron with high affinity and can also use three xenosiderophores secreted by other microorganisms, ferrichrome, coprogen, and ferrioxamine. Here we focused on FoxA, a TonB-dependent transporter of ferrioxamines. Adjacent to foxA is a gene annotated as a helix-turn-helix (HTH) domain-containing protein, SL0358 (foxR), in the Salmonella enterica serovar Typhimurium SL1344 genome. FoxR shares homology with transcriptional regulators belonging to the AraC/XylS family. foxR is syntenic with foxA in the Enterobacteriaceae family, suggesting their functional relatedness. Both foxA and foxR are repressed by the ferric uptake regulator (Fur) under iron-rich growth conditions. When iron is scarce, FoxR acts as a transcriptional activator of foxA b"],"journal":["Molecular microbiology"],"pagination":["369-386"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9804782"],"repository":["biostudies-literature"],"pubmed_title":["FoxR is an AraC-like transcriptional regulator of ferrioxamine uptake in Salmonella enterica."],"pmcid":["PMC9804782"],"pubmed_authors":["Knodler LA","Saldana-Ahuactzi Z"],"additional_accession":[]},"is_claimable":false,"name":"FoxR is an AraC-like transcriptional regulator of ferrioxamine uptake in Salmonella enterica.","description":"Salmonella enterica spp. produce siderophores to bind iron with high affinity and can also use three xenosiderophores secreted by other microorganisms, ferrichrome, coprogen, and ferrioxamine. Here we focused on FoxA, a TonB-dependent transporter of ferrioxamines. Adjacent to foxA is a gene annotated as a helix-turn-helix (HTH) domain-containing protein, SL0358 (foxR), in the Salmonella enterica serovar Typhimurium SL1344 genome. FoxR shares homology with transcriptional regulators belonging to the AraC/XylS family. foxR is syntenic with foxA in the Enterobacteriaceae family, suggesting their functional relatedness. Both foxA and foxR are repressed by the ferric uptake regulator (Fur) under iron-rich growth conditions. When iron is scarce, FoxR acts as a transcriptional activator of foxA b","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-05-28T03:47:05.616Z","creation":"2025-04-06T00:52:39.207Z"},"accession":"S-EPMC9804782","cross_references":{"pubmed":["35970762"],"doi":["10.1111/mmi.14970"]}}