{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28(55)"],"submitter":["Solea AB"],"funding":["HES-SO Projects"],"pubmed_abstract":["The toxicity of phosgene (COCl<sub>2</sub> ) combined with its extensive use as a reactant and building block in the chemical industry make its fast and accurate detection a prerequisite. We have developed a carboxylic derivative of 5,6-pinenepyridine which is able to act as colorimetric and fluorimetric sensor for phosgene in air and solution. For the first time, the formation of a pyrido-[2,1-a]isoindolone was used for this purpose. In solution, the sensing reaction is extremely fast (under 5 s), selective and highly sensitive, with a limit of detection (LOD) of 9.7 nM/0.8 ppb. When fixed on a solid support, the sensor is able to detect the presence of gaseous phosgene down to concentrations of 0.1 ppm, one of the lowest values reported to date."],"journal":["Chemistry (Weinheim an der Bergstrasse, Germany)"],"pagination":["e202201772"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9804803"],"repository":["biostudies-literature"],"pubmed_title":["A Rapid, Highly Sensitive and Selective Phosgene Sensor Based on 5,6-Pinenepyridine."],"pmcid":["PMC9804803"],"pubmed_authors":["Mamula Steiner O","Allemann C","Solea AB","Fromm KM","Curty C"],"additional_accession":[]},"is_claimable":false,"name":"A Rapid, Highly Sensitive and Selective Phosgene Sensor Based on 5,6-Pinenepyridine.","description":"The toxicity of phosgene (COCl<sub>2</sub> ) combined with its extensive use as a reactant and building block in the chemical industry make its fast and accurate detection a prerequisite. We have developed a carboxylic derivative of 5,6-pinenepyridine which is able to act as colorimetric and fluorimetric sensor for phosgene in air and solution. For the first time, the formation of a pyrido-[2,1-a]isoindolone was used for this purpose. In solution, the sensing reaction is extremely fast (under 5 s), selective and highly sensitive, with a limit of detection (LOD) of 9.7 nM/0.8 ppb. When fixed on a solid support, the sensor is able to detect the presence of gaseous phosgene down to concentrations of 0.1 ppm, one of the lowest values reported to date.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T19:56:14.92Z","creation":"2025-04-04T19:56:14.92Z"},"accession":"S-EPMC9804803","cross_references":{"pubmed":["35731617"],"doi":["10.1002/chem.202201772"]}}