biostudies-literatureUnknown88(6)Seginer A<h4>Purpose</h4>Fast proton (¹ H) MRSI is an important diagnostic tool for clinical investigations, providing metabolic and spatial information. MRSI at 7 T benefits from increased SNR and improved separation of peaks but requires larger spectral widths. RS-COKE (Readout-Segmented Consistent K-t space Epsi) is an echo planar spectroscopic imaging (Epsi) variant capable to support the spectral width required for human brain metabolites spectra at 7 T. However, mismatches between readout segments lead to artifacts, particularly when subcutaneous lipid signals are not suppressed. In this study, these mismatches and their effects are analyzed and reduced.<h4>Methods</h4>The following corrections to the data were performed: i) frequency-dependent phase corrections; ii) k-space trajecMagnetic resonance in medicine2339-2357https://www.ebi.ac.uk/biostudies/studies/S-EPMC9804880biostudies-literatureArtifact suppression in readout-segmented consistent K-t space EPSI (RS-COKE) for fast ¹ H spectroscopic imaging at 7 T.PMC9804880Schmidt RSeginer AKeith GAPorter DAfalseArtifact suppression in readout-segmented consistent K-t space EPSI (RS-COKE) for fast ¹ H spectroscopic imaging at 7 T.<h4>Purpose</h4>Fast proton (¹ H) MRSI is an important diagnostic tool for clinical investigations, providing metabolic and spatial information. MRSI at 7 T benefits from increased SNR and improved separation of peaks but requires larger spectral widths. RS-COKE (Readout-Segmented Consistent K-t space Epsi) is an echo planar spectroscopic imaging (Epsi) variant capable to support the spectral width required for human brain metabolites spectra at 7 T. However, mismatches between readout segments lead to artifacts, particularly when subcutaneous lipid signals are not suppressed. In this study, these mismatches and their effects are analyzed and reduced.<h4>Methods</h4>The following corrections to the data were performed: i) frequency-dependent phase corrections; ii) k-space trajec2022-01-01T00:00:00Z2022 Dec2025-04-04T21:04:10.689Z2025-04-04T21:04:10.689ZS-EPMC98048803597596510.1002/mrm.29373