{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Garcia-Montojo M"],"funding":["ALS Association"],"pagination":["782-792"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9805205"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["92(5)"],"pubmed_abstract":["<h4>Objectives</h4>Reactivation of HERV-K(HML-2) has been found in subsets of individuals with amyotrophic lateral sclerosis (ALS). This study examines the antibody response against HML-2 in ALS and analyzes its clinical relevance.<h4>Methods</h4>Antibodies to HML-2 envelope (env) were analyzed using a peptide array for epitope mapping and by a peptide enzyme-linked immunosorbent assay (ELISA) in 242 healthy donors, and 243 ALS and 85 multiple sclerosis (MS) individuals. Extracellular levels of HML-2 were analyzed by digital polymerase chain reaction (PCR).<h4>Results</h4>Antibodies in the sera of ALS individuals recognized more HML-2 env peptides compared to healthy controls (p < 0.0001). ALS individuals had higher levels of HML-2 than healthy donors (p = 0.02) and higher antibody levels "],"journal":["Annals of neurology"],"pubmed_title":["Antibody Response to HML-2 May Be Protective in Amyotrophic Lateral Sclerosis."],"pmcid":["PMC9805205"],"funding_grant_id":["20‐SI‐559"],"pubmed_authors":["Fathi S","Simula ER","Johnson K","Berry JD","Nath A","Cudkowicz M","Sechi LA","Garcia-Montojo M","Ghosal A","Norato G","McMahan C","Elkahloun A","James T","Jensen P"],"additional_accession":[]},"is_claimable":false,"name":"Antibody Response to HML-2 May Be Protective in Amyotrophic Lateral Sclerosis.","description":"<h4>Objectives</h4>Reactivation of HERV-K(HML-2) has been found in subsets of individuals with amyotrophic lateral sclerosis (ALS). This study examines the antibody response against HML-2 in ALS and analyzes its clinical relevance.<h4>Methods</h4>Antibodies to HML-2 envelope (env) were analyzed using a peptide array for epitope mapping and by a peptide enzyme-linked immunosorbent assay (ELISA) in 242 healthy donors, and 243 ALS and 85 multiple sclerosis (MS) individuals. Extracellular levels of HML-2 were analyzed by digital polymerase chain reaction (PCR).<h4>Results</h4>Antibodies in the sera of ALS individuals recognized more HML-2 env peptides compared to healthy controls (p < 0.0001). ALS individuals had higher levels of HML-2 than healthy donors (p = 0.02) and higher antibody levels ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-05-28T03:54:40.584Z","creation":"2025-02-19T02:37:49.809Z"},"accession":"S-EPMC9805205","cross_references":{"pubmed":["36053951"],"doi":["10.1002/ana.26466"]}}