{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nan J"],"funding":["Jilin University","China Postdoctoral Science Foundation","National Natural Science Foundation of China","NCI NIH HHS","State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics"],"pagination":["9596-9605"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9805804"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(23)"],"pubmed_abstract":["Clinical serology assays for detecting the antibodies of the virus are time-consuming, are less sensitive/selective, or rely on sophisticated detection instruments. Here, we develop a sandwiched plasmonic biosensor (SPB) for supersensitive thickness-sensing via utilizing the distance-dependent electromagnetic coupling in sandwiched plasmonic nanostructures. SPBs quantitatively amplify the thickness changes on the nanoscale range (sensitivity: ∼2% nm<sup>-1</sup>) into macroscopically visible signals, thereby enabling the rapid, label-free, and naked-eye detection of targeted biomolecular species (via the thickness change caused by immunobinding events). As a proof of concept, this assay affords a broad dynamic range (7 orders of magnitude) and a low LOD (∼0.3 pM), allowing for the extremely accurate SARS-CoV-2 antibody quantification (sensitivity/specificity: 100%/∼99%, with a portable optical fiber device). This strategy is suitable for high-throughput multiplexed detection and smartphone-based sensing at the point-of-care, which can be expanded for various sensing applications beyond the fields of viral infections and vaccination."],"journal":["Nano letters"],"pubmed_title":["Thickness-Sensing Sandwiched Plasmonic Biosensors Enable Label-Free Naked-Eye Antibody Quantification."],"pmcid":["PMC9805804"],"funding_grant_id":["F32 CA213620","2020M681046","21975098","2020TQ0119","2017TD-06","22275071"],"pubmed_authors":["Liu J","Shan H","Liu K","Zhang J","Yang B","Sun W","Zhang S","Wang L","Liu X","Zhang W","Che Y","Liu B","Nan J","Xu W","Yue Y","Hettie KS","Zhu S"],"additional_accession":[]},"is_claimable":false,"name":"Thickness-Sensing Sandwiched Plasmonic Biosensors Enable Label-Free Naked-Eye Antibody Quantification.","description":"Clinical serology assays for detecting the antibodies of the virus are time-consuming, are less sensitive/selective, or rely on sophisticated detection instruments. Here, we develop a sandwiched plasmonic biosensor (SPB) for supersensitive thickness-sensing via utilizing the distance-dependent electromagnetic coupling in sandwiched plasmonic nanostructures. SPBs quantitatively amplify the thickness changes on the nanoscale range (sensitivity: ∼2% nm<sup>-1</sup>) into macroscopically visible signals, thereby enabling the rapid, label-free, and naked-eye detection of targeted biomolecular species (via the thickness change caused by immunobinding events). As a proof of concept, this assay affords a broad dynamic range (7 orders of magnitude) and a low LOD (∼0.3 pM), allowing for the extremely accurate SARS-CoV-2 antibody quantification (sensitivity/specificity: 100%/∼99%, with a portable optical fiber device). This strategy is suitable for high-throughput multiplexed detection and smartphone-based sensing at the point-of-care, which can be expanded for various sensing applications beyond the fields of viral infections and vaccination.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T07:47:24.2Z","creation":"2025-04-04T07:47:24.2Z"},"accession":"S-EPMC9805804","cross_references":{"pubmed":["36394551"],"doi":["10.1021/acs.nanolett.2c03732"]}}