{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Augustin A"],"funding":["Medical Research Council","National Institute for Health Research (NIHR)"],"pagination":["e1152"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9806009"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["<h4>Background</h4>Gut-brain axis is widely implicated in the pathophysiology of Parkinson's disease (PD). We take an integrated approach to considering the gut as a target for disease-modifying intervention, using continuous measurements of disease facets irrespective of diagnostic divide.<h4>Methods</h4>We characterised 77 participants with diagnosed-PD, 113 without, by dietary/exogenous substance intake, faecal metabolome, intestinal inflammation, serum cytokines/chemokines, clinical phenotype including colonic transit time. Complete-linkage hierarchical cluster analysis of metabolites discriminant for PD-status was performed.<h4>Results</h4>Longer colonic transit was linked to deficits in faecal short-chain-fatty acids outside PD, to a 'tryptophan-containing metabolite cluster' overall"],"journal":["Clinical and translational medicine"],"pubmed_title":["Faecal metabolite deficit, gut inflammation and diet in Parkinson's disease: Integrative analysis indicates inflammatory response syndrome."],"pmcid":["PMC9806009"],"funding_grant_id":["CL-2019-21-002","MR/S010483/1"],"pubmed_authors":["Bjarnason I","Umamahesan C","Chekmeneva E","Ryan S","Lewis M","Tucker RM","Augustin A","Dobbs RJ","Ma Y","Dobbs SM","Guennec AL","Kendler-Rhodes A","Balasubramanian K","Hayee BH","DeSouza N","Ibrahim MAA","Weller C","Whelan K","Taylor D","Takis P","Mullish BH","Charlett A"],"additional_accession":[]},"is_claimable":false,"name":"Faecal metabolite deficit, gut inflammation and diet in Parkinson's disease: Integrative analysis indicates inflammatory response syndrome.","description":"<h4>Background</h4>Gut-brain axis is widely implicated in the pathophysiology of Parkinson's disease (PD). We take an integrated approach to considering the gut as a target for disease-modifying intervention, using continuous measurements of disease facets irrespective of diagnostic divide.<h4>Methods</h4>We characterised 77 participants with diagnosed-PD, 113 without, by dietary/exogenous substance intake, faecal metabolome, intestinal inflammation, serum cytokines/chemokines, clinical phenotype including colonic transit time. Complete-linkage hierarchical cluster analysis of metabolites discriminant for PD-status was performed.<h4>Results</h4>Longer colonic transit was linked to deficits in faecal short-chain-fatty acids outside PD, to a 'tryptophan-containing metabolite cluster' overall","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-05-31T22:56:30.477Z","creation":"2024-11-11T18:40:45.136Z"},"accession":"S-EPMC9806009","cross_references":{"pubmed":["36588088"],"doi":["10.1002/ctm2.1152"]}}