biostudies-literatureAugustin AMedical Research CouncilNational Institute for Health Research (NIHR)e1152https://www.ebi.ac.uk/biostudies/studies/S-EPMC9806009biostudies-literatureUnknown13(1)<h4>Background</h4>Gut-brain axis is widely implicated in the pathophysiology of Parkinson's disease (PD). We take an integrated approach to considering the gut as a target for disease-modifying intervention, using continuous measurements of disease facets irrespective of diagnostic divide.<h4>Methods</h4>We characterised 77 participants with diagnosed-PD, 113 without, by dietary/exogenous substance intake, faecal metabolome, intestinal inflammation, serum cytokines/chemokines, clinical phenotype including colonic transit time. Complete-linkage hierarchical cluster analysis of metabolites discriminant for PD-status was performed.<h4>Results</h4>Longer colonic transit was linked to deficits in faecal short-chain-fatty acids outside PD, to a 'tryptophan-containing metabolite cluster' overallClinical and translational medicineFaecal metabolite deficit, gut inflammation and diet in Parkinson's disease: Integrative analysis indicates inflammatory response syndrome.PMC9806009CL-2019-21-002MR/S010483/1Bjarnason IUmamahesan CChekmeneva ERyan SLewis MTucker RMAugustin ADobbs RJMa YDobbs SMGuennec ALKendler-Rhodes ABalasubramanian KHayee BHDeSouza NIbrahim MAAWeller CWhelan KTaylor DTakis PMullish BHCharlett AfalseFaecal metabolite deficit, gut inflammation and diet in Parkinson's disease: Integrative analysis indicates inflammatory response syndrome.<h4>Background</h4>Gut-brain axis is widely implicated in the pathophysiology of Parkinson's disease (PD). We take an integrated approach to considering the gut as a target for disease-modifying intervention, using continuous measurements of disease facets irrespective of diagnostic divide.<h4>Methods</h4>We characterised 77 participants with diagnosed-PD, 113 without, by dietary/exogenous substance intake, faecal metabolome, intestinal inflammation, serum cytokines/chemokines, clinical phenotype including colonic transit time. Complete-linkage hierarchical cluster analysis of metabolites discriminant for PD-status was performed.<h4>Results</h4>Longer colonic transit was linked to deficits in faecal short-chain-fatty acids outside PD, to a 'tryptophan-containing metabolite cluster' overall2023-01-01T00:00:00Z2023 Jan2025-05-31T22:56:30.477Z2024-11-11T18:40:45.136ZS-EPMC98060093658808810.1002/ctm2.1152