{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Yang Y"],"pubmed_abstract":["Benzylisoquinoline alkaloids (BIAs) are a large family of plant natural products with important pharmaceutical applications. <i>Sinomenium acutum</i> is a medicinal plant from the Menispermaceae family and has been used to treat rheumatoid arthritis for hundreds of years. <i>Sinomenium acutum</i> contains more than 50 BIAs, and sinomenine is a representative BIA from this plant. Sinomenine was found to have preventive and curative effects on opioid dependence. Despite the broad applications of <i>S. acutum</i>, investigation on the biosynthetic pathways of BIAs from <i>S. acutum</i> is limited. In this study, we comprehensively analyzed the transcriptome data and BIAs in the root, stem, leaf, and seed of <i>S. acutum</i>. Metabolic analysis showed a noticeable difference in BIA contents in"],"journal":["Frontiers in plant science"],"pagination":["1086335"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9808091"],"repository":["biostudies-literature"],"pubmed_title":["Full-length transcriptome and metabolite analysis reveal reticuline epimerase-independent pathways for benzylisoquinoline alkaloids biosynthesis in <i>Sinomenium acutum</i>."],"pmcid":["PMC9808091"],"pubmed_authors":["Yang Y","Sun R","Wang C","Huang X","Xue L","Yin M","Sun Y","Wang Z","Yan X"],"additional_accession":[]},"is_claimable":false,"name":"Full-length transcriptome and metabolite analysis reveal reticuline epimerase-independent pathways for benzylisoquinoline alkaloids biosynthesis in <i>Sinomenium acutum</i>.","description":"Benzylisoquinoline alkaloids (BIAs) are a large family of plant natural products with important pharmaceutical applications. <i>Sinomenium acutum</i> is a medicinal plant from the Menispermaceae family and has been used to treat rheumatoid arthritis for hundreds of years. <i>Sinomenium acutum</i> contains more than 50 BIAs, and sinomenine is a representative BIA from this plant. Sinomenine was found to have preventive and curative effects on opioid dependence. Despite the broad applications of <i>S. acutum</i>, investigation on the biosynthetic pathways of BIAs from <i>S. acutum</i> is limited. In this study, we comprehensively analyzed the transcriptome data and BIAs in the root, stem, leaf, and seed of <i>S. acutum</i>. Metabolic analysis showed a noticeable difference in BIA contents in","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T13:52:52.778Z","creation":"2025-04-04T13:52:52.778Z"},"accession":"S-EPMC9808091","cross_references":{"pubmed":["36605968"],"doi":["10.3389/fpls.2022.1086335"]}}