{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(6)"],"submitter":["Rajeshkumar RR"],"pubmed_abstract":["<i><b>Introduction:</b> </i> Parkinson's disease (PD) is a chronic, devastating neurodegenerative disorder marked by the death of dopaminergic neurons in the midbrain's substantia nigra pars compacta (Snpc). In alpha-synuclein (α-Syn) self-aggregation, the existence of intracytoplasmic inclusion bodies called Lewy bodies (LBs) and Lewy neurites (LNs) causes PD, which is a cause of neuronal death. <i><b>Methods:</b> </i> The present study is aimed at finding potential bioactive compounds from <i>Cynodon dectylon</i> that can degrade α-Syn aggregation in the brain, through <i>in silico</i> molecular docking investigations. Graph theoretical network analysis was used to identify the bioactive compounds that target α-Syn and decipher their network as a graph. From the data repository, twenty-n"],"journal":["BioImpacts : BI"],"pagination":["487-499"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9809135"],"repository":["biostudies-literature"],"pubmed_title":["Graph theoretical network analysis, <i>in silico</i> exploration, and validation of bioactive compounds from <i>Cynodon dactylon</i> as potential neuroprotective agents against α-synuclein."],"pmcid":["PMC9809135"],"pubmed_authors":["Murugesan S","Panneerselvam T","Kabilan SJ","Parasuraman P","Kumar BK","Sundar K","Kunjiappan S","Rajeshkumar RR","Ram Kumar Pandian S","Ammunje DN"],"additional_accession":[]},"is_claimable":false,"name":"Graph theoretical network analysis, <i>in silico</i> exploration, and validation of bioactive compounds from <i>Cynodon dactylon</i> as potential neuroprotective agents against α-synuclein.","description":"<i><b>Introduction:</b> </i> Parkinson's disease (PD) is a chronic, devastating neurodegenerative disorder marked by the death of dopaminergic neurons in the midbrain's substantia nigra pars compacta (Snpc). In alpha-synuclein (α-Syn) self-aggregation, the existence of intracytoplasmic inclusion bodies called Lewy bodies (LBs) and Lewy neurites (LNs) causes PD, which is a cause of neuronal death. <i><b>Methods:</b> </i> The present study is aimed at finding potential bioactive compounds from <i>Cynodon dectylon</i> that can degrade α-Syn aggregation in the brain, through <i>in silico</i> molecular docking investigations. Graph theoretical network analysis was used to identify the bioactive compounds that target α-Syn and decipher their network as a graph. From the data repository, twenty-n","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-27T23:23:11.695Z","creation":"2024-12-03T22:58:53.055Z"},"accession":"S-EPMC9809135","cross_references":{"pubmed":["36644543"],"doi":["10.34172/bi.2022.24113"]}}