biostudies-literatureUnknown12(6)Rajeshkumar RR<i><b>Introduction:</b> </i> Parkinson's disease (PD) is a chronic, devastating neurodegenerative disorder marked by the death of dopaminergic neurons in the midbrain's substantia nigra pars compacta (Snpc). In alpha-synuclein (α-Syn) self-aggregation, the existence of intracytoplasmic inclusion bodies called Lewy bodies (LBs) and Lewy neurites (LNs) causes PD, which is a cause of neuronal death. <i><b>Methods:</b> </i> The present study is aimed at finding potential bioactive compounds from <i>Cynodon dectylon</i> that can degrade α-Syn aggregation in the brain, through <i>in silico</i> molecular docking investigations. Graph theoretical network analysis was used to identify the bioactive compounds that target α-Syn and decipher their network as a graph. From the data repository, twenty-nBioImpacts : BI487-499https://www.ebi.ac.uk/biostudies/studies/S-EPMC9809135biostudies-literatureGraph theoretical network analysis, <i>in silico</i> exploration, and validation of bioactive compounds from <i>Cynodon dactylon</i> as potential neuroprotective agents against α-synuclein.PMC9809135Murugesan SPanneerselvam TKabilan SJParasuraman PKumar BKSundar KKunjiappan SRajeshkumar RRRam Kumar Pandian SAmmunje DNfalseGraph theoretical network analysis, <i>in silico</i> exploration, and validation of bioactive compounds from <i>Cynodon dactylon</i> as potential neuroprotective agents against α-synuclein.<i><b>Introduction:</b> </i> Parkinson's disease (PD) is a chronic, devastating neurodegenerative disorder marked by the death of dopaminergic neurons in the midbrain's substantia nigra pars compacta (Snpc). In alpha-synuclein (α-Syn) self-aggregation, the existence of intracytoplasmic inclusion bodies called Lewy bodies (LBs) and Lewy neurites (LNs) causes PD, which is a cause of neuronal death. <i><b>Methods:</b> </i> The present study is aimed at finding potential bioactive compounds from <i>Cynodon dectylon</i> that can degrade α-Syn aggregation in the brain, through <i>in silico</i> molecular docking investigations. Graph theoretical network analysis was used to identify the bioactive compounds that target α-Syn and decipher their network as a graph. From the data repository, twenty-n2022-01-01T00:00:00Z20222026-05-27T23:23:11.695Z2024-12-03T22:58:53.055ZS-EPMC98091353664454310.34172/bi.2022.24113