{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(15)"],"submitter":["Feng Y"],"pubmed_abstract":["<b>Background:</b> miR-143 is known to be downregulated in various cancer cells and tumors and generally plays a tumor-suppressor role. miR-143. However, the role of miR-143 in the mediation of the sensitivity of prostate cancer cells to abiraterone acetate remains unrevealed. <b>Methods:</b> The expression levels of miRNAs were determined by miRNA microarray and quantitative real-time PCR (qRT-PCR). The protein levels were assessed by Western blot assay. Cell viability and apoptosis were respectively measured by Cell Counting Kit-8 (CCK-8) assay and flow cytometry. <b>Results:</b> We identified that miR-143 was significantly downregulated in PC3-AbiR cells compared to PC3 cells. Overexpression of miR-143 promoted PC-AbiR sensitivity to abiraterone acetate in vitro and in vivo. We also rev"],"journal":["Journal of Cancer"],"pagination":["3652-3659"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9809307"],"repository":["biostudies-literature"],"pubmed_title":["miR-143 mediates abiraterone acetate resistance by regulating the JNK/Bcl-2 signaling pathway in prostate cancer."],"pmcid":["PMC9809307"],"pubmed_authors":["Gao R","Cao H","Feng Y","Chen L","Wang D","Zhao W"],"additional_accession":[]},"is_claimable":false,"name":"miR-143 mediates abiraterone acetate resistance by regulating the JNK/Bcl-2 signaling pathway in prostate cancer.","description":"<b>Background:</b> miR-143 is known to be downregulated in various cancer cells and tumors and generally plays a tumor-suppressor role. miR-143. However, the role of miR-143 in the mediation of the sensitivity of prostate cancer cells to abiraterone acetate remains unrevealed. <b>Methods:</b> The expression levels of miRNAs were determined by miRNA microarray and quantitative real-time PCR (qRT-PCR). The protein levels were assessed by Western blot assay. Cell viability and apoptosis were respectively measured by Cell Counting Kit-8 (CCK-8) assay and flow cytometry. <b>Results:</b> We identified that miR-143 was significantly downregulated in PC3-AbiR cells compared to PC3 cells. Overexpression of miR-143 promoted PC-AbiR sensitivity to abiraterone acetate in vitro and in vivo. We also rev","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T09:21:41.886Z","creation":"2025-04-19T09:21:41.886Z"},"accession":"S-EPMC9809307","cross_references":{"pubmed":["36606191"],"doi":["10.7150/jca.78246"]}}