biostudies-literatureUnknown13Garrido JMedical cannabis (<i>Cannabis sativa</i> L.) is a source of bioactive phytochemicals with promising pharmacological and therapeutic applications. Enhancing the accumulation of valuable bioactive compounds is potentially a way of increasing the economic importance of this crop. Signaling molecules like salicylic acid (SA), jasmonic acid (JA), and γ-aminobutyric acid (GABA) are involved in the regulation of plant development and responses to biotic and abiotic stresses. Moreover, several phytohormones regulate plant trichome formation and elicit the synthesis of secondary metabolites in many plant species in both <i>in vitro</i> and <i>in vivo</i> systems. Therefore, exogenously delivered plant signaling molecules have the potential to modify the chemical profiles of medical cannabis. In thiFrontiers in plant science1082554https://www.ebi.ac.uk/biostudies/studies/S-EPMC9809906biostudies-literatureExogenous application of stress-related signaling molecules affect growth and cannabinoid accumulation in medical cannabis (<i>Cannabis sativa</i> L.).PMC9809906Rico SCorral CSanchez CGarrido JMartinez-Quesada JJVidal NFerreiro-Vera CfalseExogenous application of stress-related signaling molecules affect growth and cannabinoid accumulation in medical cannabis (<i>Cannabis sativa</i> L.).Medical cannabis (<i>Cannabis sativa</i> L.) is a source of bioactive phytochemicals with promising pharmacological and therapeutic applications. Enhancing the accumulation of valuable bioactive compounds is potentially a way of increasing the economic importance of this crop. Signaling molecules like salicylic acid (SA), jasmonic acid (JA), and γ-aminobutyric acid (GABA) are involved in the regulation of plant development and responses to biotic and abiotic stresses. Moreover, several phytohormones regulate plant trichome formation and elicit the synthesis of secondary metabolites in many plant species in both <i>in vitro</i> and <i>in vivo</i> systems. Therefore, exogenously delivered plant signaling molecules have the potential to modify the chemical profiles of medical cannabis. In thi2022-01-01T00:00:00Z20222025-04-05T15:03:55.323Z2025-04-05T15:03:55.323ZS-EPMC98099063660595110.3389/fpls.2022.1082554