{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lim CY"],"funding":["Ministry of Science and Technology, Taiwan","NIA NIH HHS","NIH HHS","National Institute on Aging"],"pagination":["224-240"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9809948"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["Dietary restriction (DR) is known to promote autophagy to exert its longevity effect. While SAMS-1 (S-adenosyl methionine synthetase-1) has been shown to be a key mediator of the DR response, little is known about the roles of S-adenosyl methionine (SAM) and SAM-dependent methyltransferase in autophagy and DR-induced longevity. In this study, we show that DR and SAMS-1 repress the activity of SET-2, a histone H3K4 methyltransferase, by limiting the availability of SAM. Consequently, the reduced H3K4me3 levels promote the expression and activity of two transcription factors, HLH-30/TFEB and PHA-4/FOXA, which both regulate the transcription of autophagy-related genes. We then find that HLH-30/TFEB and PHA-4/FOXA act collaboratively on their common target genes to mediate the transcriptional "],"journal":["Autophagy"],"pubmed_title":["SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity."],"pmcid":["PMC9809948"],"funding_grant_id":["R01 AG072791","MOST 109-2628-B010-012","R21 AG058038","MOST 110-2311-B-A49A-502","P40 OD010440","AG058038","R01 AG028664","AG028664","R01 AG038664"],"pubmed_authors":["Lin HT","Wang FY","Lu TC","Ching TT","Kang YH","Hsu AL","Lim CY","Kumsta C","Hansen M"],"additional_accession":[]},"is_claimable":false,"name":"SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity.","description":"Dietary restriction (DR) is known to promote autophagy to exert its longevity effect. While SAMS-1 (S-adenosyl methionine synthetase-1) has been shown to be a key mediator of the DR response, little is known about the roles of S-adenosyl methionine (SAM) and SAM-dependent methyltransferase in autophagy and DR-induced longevity. In this study, we show that DR and SAMS-1 repress the activity of SET-2, a histone H3K4 methyltransferase, by limiting the availability of SAM. Consequently, the reduced H3K4me3 levels promote the expression and activity of two transcription factors, HLH-30/TFEB and PHA-4/FOXA, which both regulate the transcription of autophagy-related genes. We then find that HLH-30/TFEB and PHA-4/FOXA act collaboratively on their common target genes to mediate the transcriptional ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-05-29T16:22:08.433Z","creation":"2025-05-29T16:22:08.433Z"},"accession":"S-EPMC9809948","cross_references":{"pubmed":["35503435"],"doi":["10.1080/15548627.2022.2068267"]}}