biostudies-literatureUnknown15(1)McKay Ithe National Health and Medical Research Council, AustraliaCystic fibrosis (CF) is a multisystem, autosomal, recessive disease primarily affecting the lungs, pancreas, gastrointestinal tract, and liver. Whilst there is increasing evidence of a microbial 'gut-lung axis' in chronic respiratory conditions, there has been limited analysis of such a concept in CF. We performed a comprehensive dietary and microbiota analysis to explore the interactions between diet, gastrointestinal microbiota, respiratory microbiota, and clinical outcomes in children with CF. Our results demonstrate significant alterations in intestinal inflammation and respiratory and gastrointestinal microbiota when compared to age and gender matched children without CF. We identified correlations between the gastrointestinal and respiratory microbiota, lung function, CF pulmonary exGut microbes2156254https://www.ebi.ac.uk/biostudies/studies/S-EPMC9809969biostudies-literatureDiet and the gut-lung axis in cystic fibrosis - direct & indirect links.PMC9809969Coffey MOwens LChuang SOoi CYDoumit MMcKay IKatz TBelessis YThomas Tvan Dorst JPrentice BJaffe AfalseDiet and the gut-lung axis in cystic fibrosis - direct & indirect links.Cystic fibrosis (CF) is a multisystem, autosomal, recessive disease primarily affecting the lungs, pancreas, gastrointestinal tract, and liver. Whilst there is increasing evidence of a microbial 'gut-lung axis' in chronic respiratory conditions, there has been limited analysis of such a concept in CF. We performed a comprehensive dietary and microbiota analysis to explore the interactions between diet, gastrointestinal microbiota, respiratory microbiota, and clinical outcomes in children with CF. Our results demonstrate significant alterations in intestinal inflammation and respiratory and gastrointestinal microbiota when compared to age and gender matched children without CF. We identified correlations between the gastrointestinal and respiratory microbiota, lung function, CF pulmonary ex2023-01-01T00:00:00Z2023 Jan-Dec2026-03-16T08:10:24.517Z2025-04-19T04:47:26.283ZS-EPMC98099693657380410.1080/19490976.2022.2156254