{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Aleman-Gomez Y"],"funding":["Swiss National Science Foundation","Faculty of Biology and Medicine of the Lausanne University","National Center of Competence in Research “SYNAPSY – “The Synaptic Bases of Mental Diseases”","Alamaya Foundation and Adrian & Simone Frutiger Foundation"],"pagination":["196-207"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9810016"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["49(1)"],"pubmed_abstract":["Background and hypothesis
Although the thalamus has a central role in schizophrenia pathophysiology, contributing to sensory, cognitive, and sleep alterations, the nature and dynamics of the alterations occurring within this structure remain largely elusive. Using a multimodal magnetic resonance imaging (MRI) approach, we examined whether anomalies: (1) differ across thalamic subregions/nuclei, (2) are already present in the early phase of psychosis (EP), and (3) worsen in chronic schizophrenia (SCHZ).Study design
T1-weighted and diffusion-weighted images were analyzed to estimate gray matter concentration (GMC) and microstructural parameters obtained from the spherical mean technique (intra-neurite volume fraction [VFINTRA)], intra-neurite diffusivity [DIFFINTRA], extra-ne"],"journal":["Schizophrenia bulletin"],"pubmed_title":["Multimodal Magnetic Resonance Imaging Depicts Widespread and Subregion Specific Anomalies in the Thalamus of Early-Psychosis and Chronic Schizophrenia Patients."],"pmcid":["PMC9810016"],"funding_grant_id":["125759","n°51AU40_125759"],"pubmed_authors":["Conus P","Aleman-Gomez Y","Klauser P","Jenni R","Do KQ","Cleusix M","Bach Cuadra M","Baumann PS","Steullet P","Baumgartner T","Hagmann P"],"additional_accession":[]},"is_claimable":false,"name":"Multimodal Magnetic Resonance Imaging Depicts Widespread and Subregion Specific Anomalies in the Thalamus of Early-Psychosis and Chronic Schizophrenia Patients.","description":"Background and hypothesis
Although the thalamus has a central role in schizophrenia pathophysiology, contributing to sensory, cognitive, and sleep alterations, the nature and dynamics of the alterations occurring within this structure remain largely elusive. Using a multimodal magnetic resonance imaging (MRI) approach, we examined whether anomalies: (1) differ across thalamic subregions/nuclei, (2) are already present in the early phase of psychosis (EP), and (3) worsen in chronic schizophrenia (SCHZ).Study design
T1-weighted and diffusion-weighted images were analyzed to estimate gray matter concentration (GMC) and microstructural parameters obtained from the spherical mean technique (intra-neurite volume fraction [VFINTRA)], intra-neurite diffusivity [DIFFINTRA], extra-ne","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-19T04:59:22.46Z","creation":"2025-04-19T04:59:22.46Z"},"accession":"S-EPMC9810016","cross_references":{"pubmed":["36065156"],"doi":["10.1093/schbul/sbac113"]}}