biostudies-literatureAleman-Gomez YSwiss National Science FoundationFaculty of Biology and Medicine of the Lausanne UniversityNational Center of Competence in Research “SYNAPSY – “The Synaptic Bases of Mental Diseases”Alamaya Foundation and Adrian &amp; Simone Frutiger Foundation196-207https://www.ebi.ac.uk/biostudies/studies/S-EPMC9810016biostudies-literatureUnknown49(1)<h4>Background and hypothesis</h4>Although the thalamus has a central role in schizophrenia pathophysiology, contributing to sensory, cognitive, and sleep alterations, the nature and dynamics of the alterations occurring within this structure remain largely elusive. Using a multimodal magnetic resonance imaging (MRI) approach, we examined whether anomalies: (1) differ across thalamic subregions/nuclei, (2) are already present in the early phase of psychosis (EP), and (3) worsen in chronic schizophrenia (SCHZ).<h4>Study design</h4>T1-weighted and diffusion-weighted images were analyzed to estimate gray matter concentration (GMC) and microstructural parameters obtained from the spherical mean technique (intra-neurite volume fraction [VFINTRA)], intra-neurite diffusivity [DIFFINTRA], extra-neSchizophrenia bulletinMultimodal Magnetic Resonance Imaging Depicts Widespread and Subregion Specific Anomalies in the Thalamus of Early-Psychosis and Chronic Schizophrenia Patients.PMC9810016125759n°51AU40_125759Conus PAleman-Gomez YKlauser PJenni RDo KQCleusix MBach Cuadra MBaumann PSSteullet PBaumgartner THagmann PfalseMultimodal Magnetic Resonance Imaging Depicts Widespread and Subregion Specific Anomalies in the Thalamus of Early-Psychosis and Chronic Schizophrenia Patients.<h4>Background and hypothesis</h4>Although the thalamus has a central role in schizophrenia pathophysiology, contributing to sensory, cognitive, and sleep alterations, the nature and dynamics of the alterations occurring within this structure remain largely elusive. Using a multimodal magnetic resonance imaging (MRI) approach, we examined whether anomalies: (1) differ across thalamic subregions/nuclei, (2) are already present in the early phase of psychosis (EP), and (3) worsen in chronic schizophrenia (SCHZ).<h4>Study design</h4>T1-weighted and diffusion-weighted images were analyzed to estimate gray matter concentration (GMC) and microstructural parameters obtained from the spherical mean technique (intra-neurite volume fraction [VFINTRA)], intra-neurite diffusivity [DIFFINTRA], extra-ne2023-01-01T00:00:00Z2023 Jan2025-04-19T04:59:22.46Z2025-04-19T04:59:22.46ZS-EPMC98100163606515610.1093/schbul/sbac113